Identification of dynorphin 1-8 in human placenta by mass spectrometry

Mahmoud Ahmed, Laura W. Randall, Baha Sibai, Chhabil Dass, Genevieve Fridland, Dominic M. Desiderio, Emirgul Tolun

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The human placental villus tissue contains opioid receptors and peptides. The opioid peptides extracted from the villus tissue were fractionated using reverse-phase high performance liquid chromatography and a radio-receptor assay. The presence of dynorphin 1-8 was corroborated by mass spectrometric production of (M + H)+ ion in the fast atom bombardment mode. This octa-peptide could be the natural ligand of the kappa opioid receptors present in the human placental villus tissue.

Original languageEnglish (US)
Pages (from-to)2067-2076
Number of pages10
JournalLife Sciences
Volume40
Issue number21
DOIs
StatePublished - May 25 1987
Externally publishedYes

Fingerprint

dynorphin (1-8)
Placenta
Mass spectrometry
Chorionic Villi
Mass Spectrometry
Opioid Peptides
Tissue
kappa Opioid Receptor
High performance liquid chromatography
Opioid Receptors
Reverse-Phase Chromatography
Radio
Assays
High Pressure Liquid Chromatography
Ions
Ligands
Atoms
Peptides

ASJC Scopus subject areas

  • Pharmacology

Cite this

Ahmed, M., Randall, L. W., Sibai, B., Dass, C., Fridland, G., Desiderio, D. M., & Tolun, E. (1987). Identification of dynorphin 1-8 in human placenta by mass spectrometry. Life Sciences, 40(21), 2067-2076. https://doi.org/10.1016/0024-3205(87)90099-3

Identification of dynorphin 1-8 in human placenta by mass spectrometry. / Ahmed, Mahmoud; Randall, Laura W.; Sibai, Baha; Dass, Chhabil; Fridland, Genevieve; Desiderio, Dominic M.; Tolun, Emirgul.

In: Life Sciences, Vol. 40, No. 21, 25.05.1987, p. 2067-2076.

Research output: Contribution to journalArticle

Ahmed, M, Randall, LW, Sibai, B, Dass, C, Fridland, G, Desiderio, DM & Tolun, E 1987, 'Identification of dynorphin 1-8 in human placenta by mass spectrometry', Life Sciences, vol. 40, no. 21, pp. 2067-2076. https://doi.org/10.1016/0024-3205(87)90099-3
Ahmed M, Randall LW, Sibai B, Dass C, Fridland G, Desiderio DM et al. Identification of dynorphin 1-8 in human placenta by mass spectrometry. Life Sciences. 1987 May 25;40(21):2067-2076. https://doi.org/10.1016/0024-3205(87)90099-3
Ahmed, Mahmoud ; Randall, Laura W. ; Sibai, Baha ; Dass, Chhabil ; Fridland, Genevieve ; Desiderio, Dominic M. ; Tolun, Emirgul. / Identification of dynorphin 1-8 in human placenta by mass spectrometry. In: Life Sciences. 1987 ; Vol. 40, No. 21. pp. 2067-2076.
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