Identification of dynorphin 1-8 in human placenta by mass spectrometry

Mahmoud S. Ahmed, Laura W. Randall, Baha Sibai, Chhabil Dass, Genevieve Fridland, Dominic M. Desiderio, Emirgul Tolun

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The human placental villus tissue contains opioid receptors and peptides. The opioid peptides extracted from the villus tissue were fractionated using reverse-phase high performance liquid chromatography and a radio-receptor assay. The presence of dynorphin 1-8 was corroborated by mass spectrometric production of (M + H)+ ion in the fast atom bombardment mode. This octa-peptide could be the natural ligand of the kappa opioid receptors present in the human placental villus tissue.

Original languageEnglish (US)
Pages (from-to)2067-2076
Number of pages10
JournalLife Sciences
Volume40
Issue number21
DOIs
StatePublished - May 25 1987
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Ahmed, M. S., Randall, L. W., Sibai, B., Dass, C., Fridland, G., Desiderio, D. M., & Tolun, E. (1987). Identification of dynorphin 1-8 in human placenta by mass spectrometry. Life Sciences, 40(21), 2067-2076. https://doi.org/10.1016/0024-3205(87)90099-3