Identification of early disease progression in an ALS rat model

Jason R. Thonhoff, Paivi M. Jordan, Joseph R. Karam, Brandon L. Bassett, Ping Wu

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Transgenic rat models of amyotrophic lateral sclerosis (ALS) have recently been developed. Most assays of ALS-symptoms in these models monitor disease onset accurately, but do not identify individuals that will develop these symptoms before the motor deficits become apparent. Peak bodyweight has recently been shown to indicate affected individuals before motor deficits become apparent. However, it must be determined retrospectively due to weight fluctuation. Here, we report that exploratory activities detected by a photobeam activity system (PAS) and wire mesh ascending test can be used to detect slight motor deficits in the early phase of ALS. Thus, these tests may be used in addition to peak bodyweight to monitor early disease progression and to assay efficacy of new therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)264-268
Number of pages5
JournalNeuroscience Letters
Volume415
Issue number3
DOIs
StatePublished - Mar 30 2007

Keywords

  • Amyotrophic lateral sclerosis (ALS)
  • Motor function
  • Superoxide dismutase 1
  • Transgenic rat

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Identification of early disease progression in an ALS rat model'. Together they form a unique fingerprint.

  • Cite this