Identification of human appendicitis by in vitro nuclear magnetic resonance

Danny O. Jacobs, R. G. Settle, John R. Clarke, Scott O. Trerotola, A. K. Sachdeva, Gerald L. Wolf, John L. Rombeau

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The spin-lattice relaxation time, T1 as determined by nuclear magnetic resonance techniques, correlates positively with tissue water content. The latter relationship has been observed in rabbits with experimentally induced appendicitis whose inflamed appendiceal tissues had significantly higher T1's and water contents than tissue from normal controls. The present experiment studied these relationships in humans. Tissue water content and T1 were measured on appendiceal tissue from 10 patients with documented appendicitis and from 6 controls without the disease. All T1's were determined within 30-60 min of removal of the appendix at operation. The mean in vitro T1 of appendiceal tissue from patients with appendicitis was significantly higher than that of controls (527 ± 15 msec versus 430 ± 17 msec, mean ± SEM, P < 0.002). In addition, a strong positive correlation was noted between T1 and tissue water content (r = 0.70, P < 0.01). Based on these findings, the use of in vivo magnetic resonance imaging techniques to detect human appendicitis noninvasively warrants investigation.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalJournal of Surgical Research
Volume48
Issue number2
DOIs
StatePublished - 1990
Externally publishedYes

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Forensic Anthropology
Appendicitis
Magnetic Resonance Spectroscopy
Water
In Vitro Techniques
Magnetic Resonance Imaging
Rabbits

ASJC Scopus subject areas

  • Surgery

Cite this

Jacobs, D. O., Settle, R. G., Clarke, J. R., Trerotola, S. O., Sachdeva, A. K., Wolf, G. L., & Rombeau, J. L. (1990). Identification of human appendicitis by in vitro nuclear magnetic resonance. Journal of Surgical Research, 48(2), 107-110. https://doi.org/10.1016/0022-4804(90)90200-L

Identification of human appendicitis by in vitro nuclear magnetic resonance. / Jacobs, Danny O.; Settle, R. G.; Clarke, John R.; Trerotola, Scott O.; Sachdeva, A. K.; Wolf, Gerald L.; Rombeau, John L.

In: Journal of Surgical Research, Vol. 48, No. 2, 1990, p. 107-110.

Research output: Contribution to journalArticle

Jacobs, DO, Settle, RG, Clarke, JR, Trerotola, SO, Sachdeva, AK, Wolf, GL & Rombeau, JL 1990, 'Identification of human appendicitis by in vitro nuclear magnetic resonance', Journal of Surgical Research, vol. 48, no. 2, pp. 107-110. https://doi.org/10.1016/0022-4804(90)90200-L
Jacobs DO, Settle RG, Clarke JR, Trerotola SO, Sachdeva AK, Wolf GL et al. Identification of human appendicitis by in vitro nuclear magnetic resonance. Journal of Surgical Research. 1990;48(2):107-110. https://doi.org/10.1016/0022-4804(90)90200-L
Jacobs, Danny O. ; Settle, R. G. ; Clarke, John R. ; Trerotola, Scott O. ; Sachdeva, A. K. ; Wolf, Gerald L. ; Rombeau, John L. / Identification of human appendicitis by in vitro nuclear magnetic resonance. In: Journal of Surgical Research. 1990 ; Vol. 48, No. 2. pp. 107-110.
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