Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein

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Abstract

Using a panel of neutralizing monoclonal antibodies, we have mapped epitopes in domain III of the envelope protein of the New York strain of West Nile virus. The ability of monoclonal antibodies that recognize these epitopes to neutralize virus appeared to differ between lineage I and II West Nile virus strains, and epitopes were located on the upper surface of domain III at residues E307, E330, and E332.

Original languageEnglish (US)
Pages (from-to)13097-13100
Number of pages4
JournalJournal of Virology
Volume76
Issue number24
DOIs
StatePublished - Dec 2002

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Viral Envelope Proteins
West Nile virus
neutralization
epitopes
Epitopes
monoclonal antibodies
Monoclonal Antibodies
proteins
Neutralizing Antibodies
neutralizing antibodies
Viruses
viruses
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

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title = "Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein",
abstract = "Using a panel of neutralizing monoclonal antibodies, we have mapped epitopes in domain III of the envelope protein of the New York strain of West Nile virus. The ability of monoclonal antibodies that recognize these epitopes to neutralize virus appeared to differ between lineage I and II West Nile virus strains, and epitopes were located on the upper surface of domain III at residues E307, E330, and E332.",
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