Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein

David W.C. Beasley; Alan D.T. Barrett

doi:10.1128/JVI.76.24.13097-13100.2002

Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein

David W.C. Beasley, Alan D.T. Barrett

Research output: Contribution to journal › Article › peer-review

230 Scopus citations

Abstract

Using a panel of neutralizing monoclonal antibodies, we have mapped epitopes in domain III of the envelope protein of the New York strain of West Nile virus. The ability of monoclonal antibodies that recognize these epitopes to neutralize virus appeared to differ between lineage I and II West Nile virus strains, and epitopes were located on the upper surface of domain III at residues E307, E330, and E332.

Original language	English (US)
Pages (from-to)	13097-13100
Number of pages	4
Journal	Journal of virology
Volume	76
Issue number	24
DOIs	https://doi.org/10.1128/JVI.76.24.13097-13100.2002
State	Published - Dec 2002

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.76.24.13097-13100.2002

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title = "Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein",

abstract = "Using a panel of neutralizing monoclonal antibodies, we have mapped epitopes in domain III of the envelope protein of the New York strain of West Nile virus. The ability of monoclonal antibodies that recognize these epitopes to neutralize virus appeared to differ between lineage I and II West Nile virus strains, and epitopes were located on the upper surface of domain III at residues E307, E330, and E332.",

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AB - Using a panel of neutralizing monoclonal antibodies, we have mapped epitopes in domain III of the envelope protein of the New York strain of West Nile virus. The ability of monoclonal antibodies that recognize these epitopes to neutralize virus appeared to differ between lineage I and II West Nile virus strains, and epitopes were located on the upper surface of domain III at residues E307, E330, and E332.

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Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein

Abstract

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