Identification of patients with cholesterol or pigment gallstones by discriminant analysis of radiographic features

S. M. Dolgin, J. S. Schwartz, H. Y. Kressel, R. D. Soloway, W. T. Miller, B. W. Trotman, A. S. Soloway, L. I. Good

Research output: Contribution to journalArticle

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Abstract

In a search for a way to distinguish cholesterol gallstones from pigment gallstones by oral cholecystography, we evaluated 56 patients with surgically confirmed cholelithiasis. Only buoyancy was highly predictive of gallstone composition: all 14 patients with floating stones had cholesterol stones (P<0.01), but only one third of the patients with cholesterol stones had stone buoyancy. Using a function derived by stepwise discriminant analysis, we separated patients with cholesterol stones from those with pigment stones. The predictive accuracy was significantly improved: sensitivity was 95 per cent (37 of 39 patients with cholesterol stones), specificity was 82 per cent (14 of 17 patients with pigment stones), and efficiency was 91 per cent (51 of 56 total patients). The resultant function, applied prospectively to 17 additional cases, classified all of them correctly. In patients with cholelithiasis and gallbladders visualized on oral cholecystography, discriminant analysis can improve the prediction of gallstone composition and the subsequent selection of medical or surgical therapy.

Original languageEnglish (US)
Pages (from-to)808-811
Number of pages4
JournalNew England Journal of Medicine
Volume304
Issue number14
StatePublished - 1981
Externally publishedYes

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Gallstones
Discriminant Analysis
Cholesterol
Cholecystography
Cholelithiasis
Gallbladder

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dolgin, S. M., Schwartz, J. S., Kressel, H. Y., Soloway, R. D., Miller, W. T., Trotman, B. W., ... Good, L. I. (1981). Identification of patients with cholesterol or pigment gallstones by discriminant analysis of radiographic features. New England Journal of Medicine, 304(14), 808-811.

Identification of patients with cholesterol or pigment gallstones by discriminant analysis of radiographic features. / Dolgin, S. M.; Schwartz, J. S.; Kressel, H. Y.; Soloway, R. D.; Miller, W. T.; Trotman, B. W.; Soloway, A. S.; Good, L. I.

In: New England Journal of Medicine, Vol. 304, No. 14, 1981, p. 808-811.

Research output: Contribution to journalArticle

Dolgin, SM, Schwartz, JS, Kressel, HY, Soloway, RD, Miller, WT, Trotman, BW, Soloway, AS & Good, LI 1981, 'Identification of patients with cholesterol or pigment gallstones by discriminant analysis of radiographic features', New England Journal of Medicine, vol. 304, no. 14, pp. 808-811.
Dolgin SM, Schwartz JS, Kressel HY, Soloway RD, Miller WT, Trotman BW et al. Identification of patients with cholesterol or pigment gallstones by discriminant analysis of radiographic features. New England Journal of Medicine. 1981;304(14):808-811.
Dolgin, S. M. ; Schwartz, J. S. ; Kressel, H. Y. ; Soloway, R. D. ; Miller, W. T. ; Trotman, B. W. ; Soloway, A. S. ; Good, L. I. / Identification of patients with cholesterol or pigment gallstones by discriminant analysis of radiographic features. In: New England Journal of Medicine. 1981 ; Vol. 304, No. 14. pp. 808-811.
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AU - Trotman, B. W.

AU - Soloway, A. S.

AU - Good, L. I.

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