Identification of the protein product of the c-mos proto-oncogene in mouse testes

N. K. Herzog, B. Singh, J. Elder, I. Lipkin, R. J. Trauger, C. F. Millette, D. S. Goldman, H. Wolfes, G. M. Cooper, R. B. Arlinghaus

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


The mouse c-mos proto-oncogene RNA is expressed primarily in mouse gonadal tissues and embryos. Until now, the c-mos protein has not been identified. Utilizing two different site-directed affinity purified anti-peptide anti-bodies, we have identified a 43 kDa c-mos protein in mouse testes and in germ cell preparations derived from testes. This 43 kDa testicular protein was found to be structurally related to a bacterially expressed c-mos protein by peptide mapping. Immunoblots of whole mouse sections were employed to establishe that the c-mos protein is expressed primarily in the testes.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
Issue number2
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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