Identification of the protein product of the c-mos proto-oncogene in mouse testes

N. K. Herzog, B. Singh, J. Elder, I. Lipkin, R. J. Trauger, C. F. Millette, D. S. Goldman, H. Wolfes, G. M. Cooper, R. B. Arlinghaus

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Abstract

The mouse c-mos proto-oncogene RNA is expressed primarily in mouse gonadal tissues and embryos. Until now, the c-mos protein has not been identified. Utilizing two different site-directed affinity purified anti-peptide anti-bodies, we have identified a 43 kDa c-mos protein in mouse testes and in germ cell preparations derived from testes. This 43 kDa testicular protein was found to be structurally related to a bacterially expressed c-mos protein by peptide mapping. Immunoblots of whole mouse sections were employed to establishe that the c-mos protein is expressed primarily in the testes.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalOncogene
Volume3
Issue number2
StatePublished - Jan 1 1988

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Herzog, N. K., Singh, B., Elder, J., Lipkin, I., Trauger, R. J., Millette, C. F., Goldman, D. S., Wolfes, H., Cooper, G. M., & Arlinghaus, R. B. (1988). Identification of the protein product of the c-mos proto-oncogene in mouse testes. Oncogene, 3(2), 225-229.