Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition

Min He, Jiyang Cai, Young Mi Go, Jennifer M. Johnson, W. David Martin, Jason M. Hansen, Dean P. Jones

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Thioredoxin-2 (Trx2) is a multifunctional, mitochondria-specific protein, which inhibits cell death. The mitochondrial permeability transition (MPT) is a distinct mechanism for cell death activated by oxidants and linked to both necrotic and apoptotic morphologies. We studied mitochondria from Trx2 transgenic mice to determine whether Trx2 protects against oxidant-induced MPT. All experiments were performed in isolated mitochondria. Results showed that Trx2 protected against MPT induced by exogenously added peroxide. Unexpectedly, Trx2 also protected against the MPT induced by Ca2+ in the absence of added peroxide. The results indicate that in addition to protecting against oxidative stress, Trx2 is an endogenous regulator of the MPT.

Original languageEnglish (US)
Pages (from-to)44-50
Number of pages7
JournalToxicological Sciences
Issue number1
StatePublished - 2008
Externally publishedYes


  • Apoptosis
  • Calcium
  • Cell death mechanisms
  • Necrosis
  • Transgenic mice

ASJC Scopus subject areas

  • Toxicology


Dive into the research topics of 'Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition'. Together they form a unique fingerprint.

Cite this