Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition

Min He, Jiyang Cai, Young Mi Go, Jennifer M. Johnson, W. David Martin, Jason M. Hansen, Dean P. Jones

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Thioredoxin-2 (Trx2) is a multifunctional, mitochondria-specific protein, which inhibits cell death. The mitochondrial permeability transition (MPT) is a distinct mechanism for cell death activated by oxidants and linked to both necrotic and apoptotic morphologies. We studied mitochondria from Trx2 transgenic mice to determine whether Trx2 protects against oxidant-induced MPT. All experiments were performed in isolated mitochondria. Results showed that Trx2 protected against MPT induced by exogenously added peroxide. Unexpectedly, Trx2 also protected against the MPT induced by Ca2+ in the absence of added peroxide. The results indicate that in addition to protecting against oxidative stress, Trx2 is an endogenous regulator of the MPT.

Original languageEnglish (US)
Pages (from-to)44-50
Number of pages7
JournalToxicological Sciences
Volume105
Issue number1
DOIs
StatePublished - 2008

Keywords

  • Apoptosis
  • Calcium
  • Cell death mechanisms
  • Necrosis
  • Transgenic mice

ASJC Scopus subject areas

  • Toxicology

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