Identity of Karelian fever and Ockelbo viruses determined by serum dilution-plaque reduction neutralization tests and oligonucleotide mapping

D. K. Lvov; E. A. Vladimirtseva; A. M. Butenko; N. Karabatsos; D. W. Trent; C. H. Calisher

doi:10.4269/ajtmh.1988.39.607

Identity of Karelian fever and Ockelbo viruses determined by serum dilution-plaque reduction neutralization tests and oligonucleotide mapping

D. K. Lvov, E. A. Vladimirtseva, A. M. Butenko, N. Karabatsos, D. W. Trent, C. H. Calisher

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The causative agents of Ockelbo disease in Sweden, Pogosta disease in Finland, and Karelian fever in the USSR have been attributed to alphaviruses (family Togaviridae) related to Sindbis virus. We compared prototypes Sindbis, Ockelbo, and Karelian fever viruses by neutralization tests. We also analyzed oligonucleotide fingerprint maps of prototypes Ockelbo and Karelian fever viruses and a strain of Sindbis virus from Czechoslovakia. The results indicate that Ockelbo and Karelian fever viruses are essentially identical and suggest that Ockelbo disease, Pogosta disease, and Karelian fever are synonyms for the same disease.

Original language	English (US)
Pages (from-to)	607-610
Number of pages	4
Journal	American Journal of Tropical Medicine and Hygiene
Volume	39
Issue number	6
DOIs	https://doi.org/10.4269/ajtmh.1988.39.607
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Virology
Infectious Diseases

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10.4269/ajtmh.1988.39.607

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title = "Identity of Karelian fever and Ockelbo viruses determined by serum dilution-plaque reduction neutralization tests and oligonucleotide mapping",

abstract = "The causative agents of Ockelbo disease in Sweden, Pogosta disease in Finland, and Karelian fever in the USSR have been attributed to alphaviruses (family Togaviridae) related to Sindbis virus. We compared prototypes Sindbis, Ockelbo, and Karelian fever viruses by neutralization tests. We also analyzed oligonucleotide fingerprint maps of prototypes Ockelbo and Karelian fever viruses and a strain of Sindbis virus from Czechoslovakia. The results indicate that Ockelbo and Karelian fever viruses are essentially identical and suggest that Ockelbo disease, Pogosta disease, and Karelian fever are synonyms for the same disease.",

author = "Lvov, {D. K.} and Vladimirtseva, {E. A.} and Butenko, {A. M.} and N. Karabatsos and Trent, {D. W.} and Calisher, {C. H.}",

year = "1988",

doi = "10.4269/ajtmh.1988.39.607",

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TY - JOUR

T1 - Identity of Karelian fever and Ockelbo viruses determined by serum dilution-plaque reduction neutralization tests and oligonucleotide mapping

AU - Lvov, D. K.

AU - Vladimirtseva, E. A.

AU - Butenko, A. M.

AU - Karabatsos, N.

AU - Trent, D. W.

AU - Calisher, C. H.

PY - 1988

Y1 - 1988

N2 - The causative agents of Ockelbo disease in Sweden, Pogosta disease in Finland, and Karelian fever in the USSR have been attributed to alphaviruses (family Togaviridae) related to Sindbis virus. We compared prototypes Sindbis, Ockelbo, and Karelian fever viruses by neutralization tests. We also analyzed oligonucleotide fingerprint maps of prototypes Ockelbo and Karelian fever viruses and a strain of Sindbis virus from Czechoslovakia. The results indicate that Ockelbo and Karelian fever viruses are essentially identical and suggest that Ockelbo disease, Pogosta disease, and Karelian fever are synonyms for the same disease.

AB - The causative agents of Ockelbo disease in Sweden, Pogosta disease in Finland, and Karelian fever in the USSR have been attributed to alphaviruses (family Togaviridae) related to Sindbis virus. We compared prototypes Sindbis, Ockelbo, and Karelian fever viruses by neutralization tests. We also analyzed oligonucleotide fingerprint maps of prototypes Ockelbo and Karelian fever viruses and a strain of Sindbis virus from Czechoslovakia. The results indicate that Ockelbo and Karelian fever viruses are essentially identical and suggest that Ockelbo disease, Pogosta disease, and Karelian fever are synonyms for the same disease.

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Identity of Karelian fever and Ockelbo viruses determined by serum dilution-plaque reduction neutralization tests and oligonucleotide mapping

Abstract

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