Identity of Karelian fever and Ockelbo viruses determined by serum dilution-plaque reduction neutralization tests and oligonucleotide mapping

D. K. Lvov, E. A. Vladimirtseva, A. M. Butenko, N. Karabatsos, D. W. Trent, C. H. Calisher

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The causative agents of Ockelbo disease in Sweden, Pogosta disease in Finland, and Karelian fever in the USSR have been attributed to alphaviruses (family Togaviridae) related to Sindbis virus. We compared prototypes Sindbis, Ockelbo, and Karelian fever viruses by neutralization tests. We also analyzed oligonucleotide fingerprint maps of prototypes Ockelbo and Karelian fever viruses and a strain of Sindbis virus from Czechoslovakia. The results indicate that Ockelbo and Karelian fever viruses are essentially identical and suggest that Ockelbo disease, Pogosta disease, and Karelian fever are synonyms for the same disease.

Original languageEnglish (US)
Pages (from-to)607-610
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume39
Issue number6
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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