TY - JOUR
T1 - Idiopathic constipation
T2 - Too few stools and too little knowledge
AU - Briejer, Michel R.
AU - Schuurkes, Jan A.J.
AU - Sarna, Sushil K.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - The precise abnormalities of colonic motility patterns in idiopathic constipation, and the alterations at the cellular, neural, myogenic and biochemical levels that underlie these patterns, are not yet understood. One promising approach in the treatment of constipation seems to be to design drugs that can stimulate GMCs to produce mass movements and consequently defaecation. This could possibly be achieved with the selective 5-HT4 receptor agonists prucalopride and SDZ HTF-919, which are currently in advanced clinical trials. Other mechanisms that provide a means to induce GMCs, such as NK1 receptor agonism, deserve further exploration.
AB - The precise abnormalities of colonic motility patterns in idiopathic constipation, and the alterations at the cellular, neural, myogenic and biochemical levels that underlie these patterns, are not yet understood. One promising approach in the treatment of constipation seems to be to design drugs that can stimulate GMCs to produce mass movements and consequently defaecation. This could possibly be achieved with the selective 5-HT4 receptor agonists prucalopride and SDZ HTF-919, which are currently in advanced clinical trials. Other mechanisms that provide a means to induce GMCs, such as NK1 receptor agonism, deserve further exploration.
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UR - http://www.scopus.com/inward/citedby.url?scp=0032973841&partnerID=8YFLogxK
U2 - 10.1016/S0165-6147(98)01278-4
DO - 10.1016/S0165-6147(98)01278-4
M3 - Short survey
C2 - 10101952
AN - SCOPUS:0032973841
SN - 0165-6147
VL - 20
SP - 1
EP - 3
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 1
ER -