IFN-γ Induces PD-L1 Expression in Primed Human Basophils

Srinivasa Reddy Bonam, Camille Chauvin, Mano J. Mathew, Jagadeesh Bayry

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Programmed death-ligand 1 (PD-L1) plays a key role in maintaining immune tolerance and also in immune evasion of cancers and pathogens. Though the identity of stimuli that induce PD-L1 in various human innate cells and their function are relatively well studied, data on the basophils remain scarce. In this study, we have identified one of the factors, such as IFN-γ, that induces PD-L1 expression in human basophils. Interestingly, we found that basophil priming by IL-3 is indispensable for IFN-γ-induced PD-L1 expression in human basophils. However, priming by other cytokines including granulocyte-macrophage colony-stimulating factor (GM-CSF) and thymic stromal lymphopoietin (TSLP) was dispensable. Analyses of a published microarray data set on IL-3-treated basophils indicated that IL-3 enhances IFNGR2, one of the chains of the IFNGR heterodimer complex, and CD274, thus providing a mechanistic insight into the role of IL-3 priming in IFN-γ-induced PD-L1 expression in human basophils.

Original languageEnglish (US)
Article number801
JournalCells
Volume11
Issue number5
DOIs
StatePublished - Mar 1 2022
Externally publishedYes

Keywords

  • Human basophils
  • IFN-γ
  • IFNGR2
  • IL-13
  • IL-3
  • IL-4
  • PD-L1

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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