IFN-γ-producing γδ T cells help control murine West Nile virus infection

Tian Wang, Eileen Scully, Zhinan Yin, Jung H. Kim, Sha Wang, Jun Yan, Mark Mamula, John F. Anderson, Joe Craft, Erol Fikrig

Research output: Contribution to journalArticlepeer-review

149 Scopus citations

Abstract

West Nile (WN) virus causes fatal meningoencephalitis in laboratory mice, thereby partially mimicking human disease. Using this model, we have demonstrated that mice deficient in γδ T cells are more susceptible to WN virus infection. TCRδ-/- mice have elevated viral loads and greater dissemination of the pathogen to the CNS. In wild-type mice, γδ T cells expanded significantly during WN virus infection, produced IFN-γ in ex vivo assays, and enhanced perforin expression by splenic T cells. Adoptive transfer of γδ T cells to TCRδ -/- mice reduced the susceptibility of these mice to WN virus, and this effect was primarily due to IFN-γ-producing γδ T cells. These data demonstrate a distinct role for γδ T cells in the control of and prevention of mortality from murine WN virus infection.

Original languageEnglish (US)
Pages (from-to)2524-2531
Number of pages8
JournalJournal of Immunology
Volume171
Issue number5
DOIs
StatePublished - Sep 1 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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