IGF binding proteins in growth-retarded children with chronic renal failure

Phillip Lee, R. L. Hintz, J. B. Sperry, R. C. Baxter, D. R. Powell

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Changes in the normal hormonal regulation of linear growth which lead to growth failure in children with chronic renal failure (CRF) are not well understood. Previous studies indicate that serum levels of growth hormone and IGF-I and II are normal or elevated in this population; and that serum levels of poorly defined inhibitors of IGF action are increased. Using a recently developed RIA for the 25-kD IGF-binding protein (IGF-BP25), we report significant elevations of this protein in children with CRF when compared to age- and sex-matched controls. IGF-BP25 levels correlate positively with IGF-binding activity in both populations, indicating that the RIA reflects levels of bioactive protein. Although the variation of serum IGF-BP25 with chronologic age and IGF levels are preserved in CRF, the quantitative interrelationships are disrupted. Levels of the 53-kG IGF-binding protein, an IGF-binding protein derived from the high mol wt IGF complex, were also found to be elevated in the CRF population and, unlike in the control population, did not vary with age or IGF levels. IGF-BP25 has been shown to inhibit IGF mitogenic action in vitro. Our finding of elevated levels of IGF-BP25 in children with CRF suggests that this protein may play a role in the growth retardation of pediatric chronic renal failure. The significance of the elevated IGF-BP35 levels in CRF remains uncertain.

Original languageEnglish (US)
Pages (from-to)308-315
Number of pages8
JournalPediatric Research
Volume26
Issue number4
StatePublished - 1989
Externally publishedYes

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Insulin-Like Growth Factor Binding Proteins
Chronic Kidney Failure
Growth
Population
Serum
Proteins
Insulin-Like Growth Factor II
Insulin-Like Growth Factor I
Protein Binding
Growth Hormone
Pediatrics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Lee, P., Hintz, R. L., Sperry, J. B., Baxter, R. C., & Powell, D. R. (1989). IGF binding proteins in growth-retarded children with chronic renal failure. Pediatric Research, 26(4), 308-315.

IGF binding proteins in growth-retarded children with chronic renal failure. / Lee, Phillip; Hintz, R. L.; Sperry, J. B.; Baxter, R. C.; Powell, D. R.

In: Pediatric Research, Vol. 26, No. 4, 1989, p. 308-315.

Research output: Contribution to journalArticle

Lee, P, Hintz, RL, Sperry, JB, Baxter, RC & Powell, DR 1989, 'IGF binding proteins in growth-retarded children with chronic renal failure', Pediatric Research, vol. 26, no. 4, pp. 308-315.
Lee P, Hintz RL, Sperry JB, Baxter RC, Powell DR. IGF binding proteins in growth-retarded children with chronic renal failure. Pediatric Research. 1989;26(4):308-315.
Lee, Phillip ; Hintz, R. L. ; Sperry, J. B. ; Baxter, R. C. ; Powell, D. R. / IGF binding proteins in growth-retarded children with chronic renal failure. In: Pediatric Research. 1989 ; Vol. 26, No. 4. pp. 308-315.
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