IgG-Fc-binding receptors in cells abortively infected, or transformed, by human cytomegalovirus.

E. Gönczöl, Istvan Boldogh, L. Váczi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Abortive human cytomegalovirus (HCMV) infection of normal hamster cells is accompanied by formation of cytoplasmic and surface receptors for the Fc portion of nonimmune IgG molecules. The process requires RNA and protein synthesis but no DNA synthesis. The surface receptors are detectable only transiently, in a small proportion of the cells. The receptors are also present in cells transformed by HCMV in vitro (87-TRH-5 and CX-90-3B cell lines) as well as in cells of lines TSC-1 and TSC-2 from tumours induced by these cells. Consequently, the indirect immunofluorescence test performed with sera containing no HCMV antibodies may give a positive reaction in the cytoplasm and/or cell membrane of the transformed cells.

Original languageEnglish (US)
Pages (from-to)157-164
Number of pages8
JournalActa Microbiologica Academiae Scientiarum Hungaricae
Volume28
Issue number2
StatePublished - 1981
Externally publishedYes

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Fc Receptors
Cytomegalovirus
Immunoglobulin G
Cell Line
Cytomegalovirus Infections
Indirect Fluorescent Antibody Technique
Cytoplasmic and Nuclear Receptors
Cricetinae
Cytoplasm
Cell Membrane
RNA
Antibodies
DNA
Serum
Neoplasms
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

IgG-Fc-binding receptors in cells abortively infected, or transformed, by human cytomegalovirus. / Gönczöl, E.; Boldogh, Istvan; Váczi, L.

In: Acta Microbiologica Academiae Scientiarum Hungaricae, Vol. 28, No. 2, 1981, p. 157-164.

Research output: Contribution to journalArticle

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