IL-22 hinders antiviral T cell responses and exacerbates ZIKV encephalitis in immunocompetent neonatal mice

Keyphrases

• T Cell Response 100%
• Virus Encephalitis 100%
• Zika Virus 100%
• Interleukin-22 (IL-22) 100%
• Neonatal Mice 100%
• Antiviral T Cells 100%
• Zika Virus Infection 38%
• Host Immunity 15%
• Spleen 15%
• Weight Loss 15%
• Glial Cells 15%
• CD8+ T Cells 15%
• Virus-specific 15%
• Post-infection 15%
• Astrocyte Activation 15%
• Microglial Activation 15%
• T Cells 7%
• Wild Mice 7%
• Infectious Diseases 7%
• Flow Cytometry 7%
• Systemic Inflammatory Response 7%
• Clinical Manifestations 7%
• Cortex 7%
• Cell Proliferation 7%
• Host Immune Response 7%
• Clinical Signs 7%
• Neurological Diseases 7%
• Pathogenic Role 7%
• Cytokine Expression 7%
• Confocal Imaging 7%
• Viral Load 7%
• Culture in Vitro 7%
• Congenital Disorders 7%
• IFNAR Mice 7%
• Hind Limb Paralysis 7%
• Effective Control 7%
• Immune Pathogenesis 7%
• Negligible Effects 7%
• Reduced Activation 7%
• Nervous System Injury 7%
• Zika Outbreak 7%
• Multiple Countries 7%
• Glial Cell Activation 7%
• Hindlimb Weakness 7%

Medicine and Dentistry

• Antivirus Agent 100%
• T-Cell Response 100%
• Virus Encephalitis 100%
• Zika Virus 100%
• Interleukin 22 100%
• Zika Fever 38%
• Infection 30%
• Microglia 30%
• In Vitro 23%
• Cytokine 15%
• Cytotoxic T-Cell 15%
• Astrocyte 15%
• T Cell 7%
• Cell Proliferation 7%
• Nervous System Injury 7%
• Flow Cytometry 7%
• Serositis 7%
• Cell Activation 7%
• Hindlimb 7%
• Weakness 7%
• Confocal Microscopy 7%
• Neurologic Disease 7%
• Immunity 7%
• Congenital Disorder 7%
• Paralysis 7%
• Glial Cells 7%

Immunology and Microbiology

• T Cell 100%
• Encephalitis 100%
• Zika Virus 100%
• Interleukin 22 100%
• Viral Disease 38%
• Microglia 30%
• Cytokine 15%
• Wild Type 15%
• Cytotoxic T-Cell 15%
• Astrocyte 15%
• Wild Type Mouse 7%
• Inflammation Response 7%
• Cell Proliferation 7%
• Cell Activation 7%
• Infectious Disease 7%
• Limb 7%
• Viral Load 7%
• Immunity 7%
• Neurological System 7%