IL-22 levels are associated with trichomonas vaginalis infection in the lower genital tract

Hadijat Moradeke Makinde, Reza Zariffard, Paria Mirmonsef, Richard M. Novak, Olamide Jarrett, Alan L. Landay, Gregory T. Spear

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Problem: IL-22 has important functions at mucosal surfaces, including the induction of antimicrobial peptides and maintenance of epithelium. However, IL-22 has not been investigated in the genital tract during TV infection. Methods of Study: Women who visited an STD clinic and women from a cohort with frequent Trichomoniasis were studied. IL-22, IL-17, and antimicrobial peptides were measured in cervicovaginal lavage by ELISA. Results: In women visiting the STD clinic, those without STDs (n = 10) had a median IL-22 of 0 pg/mL, while women with infections (n = 30) had 27 pg/mL (P = 0.04). In the cohort, women with Trichomoniasis (n = 19) had significantly higher IL-22 than women with no infections (n = 21, 74 versus 0 pg/mL, P = 0.0001). IL-17 was also significantly increased in Trichomoniasis, and there was a correlation between IL-22 and IL-17 (P = 0.001). Conclusion: IL-22 is increased in STDs generally and in Trichomoniasis specifically suggesting an antimicrobial response of the mucosa and an epithelial repair process induced by the STDs.

Original languageEnglish (US)
Pages (from-to)38-44
Number of pages7
JournalAmerican Journal of Reproductive Immunology
Volume70
Issue number1
DOIs
StatePublished - Jul 2013
Externally publishedYes

Keywords

  • Antimicrobial peptides
  • Cervicovaginal lavage
  • Genital epithelium
  • STDs
  • Trichomoniasis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

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