Image analysis microspectroscopy of senile plaque capillary amyloid in Alzheimer's disease

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The relationship between cerebral amyloid and the microvasculature in senile plaques was studied with image analysis microspectroscopy. This imaging technique permitted topography quantification of amyloid concentration within microscopic subregions of single senile plaques. The highest concentration of amyloid was measured at the walls of intraplaque capillaries. Spectroscopic images revealed a decreasing gradient of amyloid concentration with increasing distance from intraplaque capillaries. The concentration of amyloid in nonplaque capillaries was lower than that measured in capillaries within well-developed amyloid plaques. These findings support the premise that plaque amyloid deposition starts at the level of the capillary.

Original languageEnglish (US)
Pages (from-to)866-871
Number of pages6
JournalArchives of Pathology and Laboratory Medicine
Volume113
Issue number8
StatePublished - 1989
Externally publishedYes

Fingerprint

Amyloid Plaques
Amyloid
Alzheimer Disease
Microvessels

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

@article{6e2d5c9741784a4fa0d6be112ce84d6d,
title = "Image analysis microspectroscopy of senile plaque capillary amyloid in Alzheimer's disease",
abstract = "The relationship between cerebral amyloid and the microvasculature in senile plaques was studied with image analysis microspectroscopy. This imaging technique permitted topography quantification of amyloid concentration within microscopic subregions of single senile plaques. The highest concentration of amyloid was measured at the walls of intraplaque capillaries. Spectroscopic images revealed a decreasing gradient of amyloid concentration with increasing distance from intraplaque capillaries. The concentration of amyloid in nonplaque capillaries was lower than that measured in capillaries within well-developed amyloid plaques. These findings support the premise that plaque amyloid deposition starts at the level of the capillary.",
author = "Miguel Pappolla",
year = "1989",
language = "English (US)",
volume = "113",
pages = "866--871",
journal = "Archives of Pathology and Laboratory Medicine",
issn = "0003-9985",
publisher = "College of American Pathologists",
number = "8",

}

TY - JOUR

T1 - Image analysis microspectroscopy of senile plaque capillary amyloid in Alzheimer's disease

AU - Pappolla, Miguel

PY - 1989

Y1 - 1989

N2 - The relationship between cerebral amyloid and the microvasculature in senile plaques was studied with image analysis microspectroscopy. This imaging technique permitted topography quantification of amyloid concentration within microscopic subregions of single senile plaques. The highest concentration of amyloid was measured at the walls of intraplaque capillaries. Spectroscopic images revealed a decreasing gradient of amyloid concentration with increasing distance from intraplaque capillaries. The concentration of amyloid in nonplaque capillaries was lower than that measured in capillaries within well-developed amyloid plaques. These findings support the premise that plaque amyloid deposition starts at the level of the capillary.

AB - The relationship between cerebral amyloid and the microvasculature in senile plaques was studied with image analysis microspectroscopy. This imaging technique permitted topography quantification of amyloid concentration within microscopic subregions of single senile plaques. The highest concentration of amyloid was measured at the walls of intraplaque capillaries. Spectroscopic images revealed a decreasing gradient of amyloid concentration with increasing distance from intraplaque capillaries. The concentration of amyloid in nonplaque capillaries was lower than that measured in capillaries within well-developed amyloid plaques. These findings support the premise that plaque amyloid deposition starts at the level of the capillary.

UR - http://www.scopus.com/inward/record.url?scp=0024335819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024335819&partnerID=8YFLogxK

M3 - Article

C2 - 2757486

AN - SCOPUS:0024335819

VL - 113

SP - 866

EP - 871

JO - Archives of Pathology and Laboratory Medicine

JF - Archives of Pathology and Laboratory Medicine

SN - 0003-9985

IS - 8

ER -