Imaging evaluation of the adult presenting with new-onset seizure

OBJECTIVE. The purpose of this study is to discuss the evidence supporting the use of neuroimaging in adult patients presenting with new-onset seizure. CONCLUSION. Unenhanced CT should be the initial imaging examination performed for adults presenting with first unprovoked seizure in the acute setting to exclude conditions requiring urgent or emergent intervention. MRI has added benefits and should be considered for adults presenting acutely for whom the initial CT is negative and for those presenting with new-onset seizure in the nonacute setting.