Immune and non-immune responses to hepatitis C virus infection

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The host innate and adaptive immune systems are involved in nearly every step of hepatitis C virus (HCV) infection. In patients, the outcome is determined by a series of complex host-virus interactions, whether it is a natural infection or results from clinical intervention. Strong and persistent CD8+ and CD4+ T-cell responses are critical in HCV clearance, as well as cytokineinduced factors that can directly inhibit virus replication.Newly available direct-acting antivirals (DAAs) are very effective in viral clearance in patients. DAA treatment may further result in the down-regulation of programmed death-1, leading to rapid restoration of HCV-specific CD8+ T cell functions. In this review, we focus on recent studies that address the host responses critical for viral clearance and disease resolution. Additional discussion is devoted to the prophylactic vaccine development as well as to current efforts aimed at understanding the host innate responses against HCV infection. Current theories on how the ubiquitin system and interferon-stimulated genes may affect HCV replication are also discussed.

Original languageEnglish (US)
Pages (from-to)10739-10748
Number of pages10
JournalWorld Journal of Gastroenterology
Volume21
Issue number38
DOIs
StatePublished - Oct 14 2015

Fingerprint

Virus Diseases
Hepacivirus
Virus Replication
Antiviral Agents
T-Lymphocytes
Ubiquitin
Interferons
Immune System
Down-Regulation
Vaccines
Viruses
Infection
Genes

Keywords

  • Directacting antiviral
  • Hepatitis
  • Hepatitis C virus
  • Innate immune response
  • T cell

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Immune and non-immune responses to hepatitis C virus infection. / Sun, Jiaren; Rajsbaum Gorodezky, Ricardo; Yi, Min Kyung.

In: World Journal of Gastroenterology, Vol. 21, No. 38, 14.10.2015, p. 10739-10748.

Research output: Contribution to journalArticle

@article{ef5fba10e70548bfb1b5b52c38c39818,
title = "Immune and non-immune responses to hepatitis C virus infection",
abstract = "The host innate and adaptive immune systems are involved in nearly every step of hepatitis C virus (HCV) infection. In patients, the outcome is determined by a series of complex host-virus interactions, whether it is a natural infection or results from clinical intervention. Strong and persistent CD8+ and CD4+ T-cell responses are critical in HCV clearance, as well as cytokineinduced factors that can directly inhibit virus replication.Newly available direct-acting antivirals (DAAs) are very effective in viral clearance in patients. DAA treatment may further result in the down-regulation of programmed death-1, leading to rapid restoration of HCV-specific CD8+ T cell functions. In this review, we focus on recent studies that address the host responses critical for viral clearance and disease resolution. Additional discussion is devoted to the prophylactic vaccine development as well as to current efforts aimed at understanding the host innate responses against HCV infection. Current theories on how the ubiquitin system and interferon-stimulated genes may affect HCV replication are also discussed.",
keywords = "Directacting antiviral, Hepatitis, Hepatitis C virus, Innate immune response, T cell",
author = "Jiaren Sun and {Rajsbaum Gorodezky}, Ricardo and Yi, {Min Kyung}",
year = "2015",
month = "10",
day = "14",
doi = "10.3748/wjg.v21.i38.10739",
language = "English (US)",
volume = "21",
pages = "10739--10748",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "38",

}

TY - JOUR

T1 - Immune and non-immune responses to hepatitis C virus infection

AU - Sun, Jiaren

AU - Rajsbaum Gorodezky, Ricardo

AU - Yi, Min Kyung

PY - 2015/10/14

Y1 - 2015/10/14

N2 - The host innate and adaptive immune systems are involved in nearly every step of hepatitis C virus (HCV) infection. In patients, the outcome is determined by a series of complex host-virus interactions, whether it is a natural infection or results from clinical intervention. Strong and persistent CD8+ and CD4+ T-cell responses are critical in HCV clearance, as well as cytokineinduced factors that can directly inhibit virus replication.Newly available direct-acting antivirals (DAAs) are very effective in viral clearance in patients. DAA treatment may further result in the down-regulation of programmed death-1, leading to rapid restoration of HCV-specific CD8+ T cell functions. In this review, we focus on recent studies that address the host responses critical for viral clearance and disease resolution. Additional discussion is devoted to the prophylactic vaccine development as well as to current efforts aimed at understanding the host innate responses against HCV infection. Current theories on how the ubiquitin system and interferon-stimulated genes may affect HCV replication are also discussed.

AB - The host innate and adaptive immune systems are involved in nearly every step of hepatitis C virus (HCV) infection. In patients, the outcome is determined by a series of complex host-virus interactions, whether it is a natural infection or results from clinical intervention. Strong and persistent CD8+ and CD4+ T-cell responses are critical in HCV clearance, as well as cytokineinduced factors that can directly inhibit virus replication.Newly available direct-acting antivirals (DAAs) are very effective in viral clearance in patients. DAA treatment may further result in the down-regulation of programmed death-1, leading to rapid restoration of HCV-specific CD8+ T cell functions. In this review, we focus on recent studies that address the host responses critical for viral clearance and disease resolution. Additional discussion is devoted to the prophylactic vaccine development as well as to current efforts aimed at understanding the host innate responses against HCV infection. Current theories on how the ubiquitin system and interferon-stimulated genes may affect HCV replication are also discussed.

KW - Directacting antiviral

KW - Hepatitis

KW - Hepatitis C virus

KW - Innate immune response

KW - T cell

UR - http://www.scopus.com/inward/record.url?scp=84944029525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944029525&partnerID=8YFLogxK

U2 - 10.3748/wjg.v21.i38.10739

DO - 10.3748/wjg.v21.i38.10739

M3 - Article

VL - 21

SP - 10739

EP - 10748

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 38

ER -