Immune parameters correlate with protection against ebola virus infection in rodents and nonhuman primates

Gary Wong, Jason S. Richardson, Stéphane Pillet, Ami Patel, Xiangguo Qiu, Judie Alimonti, Jeff Hogan, Yi Zhang, Ayato Takada, Heinz Feldmann, Gary P. Kobinger

Research output: Contribution to journalArticlepeer-review

131 Scopus citations

Abstract

Ebola virus causes severe hemorrhagic fever in susceptible hosts. Currently, no licensed vaccines or treatments are available; however, several experimental vaccines have been successful in protecting rodents and nonhuman primates (NHPs) from the lethal Zaire ebolavirus (ZEBOV) infection. The objective of this study was to evaluate immune responses correlating with survival in these animals after lethal challenge with ZEBOV. Knockout mice with impaired ability to generate normal T and/or B cell responses were vaccinated and challenged with ZEBOV. Vaccine-induced protection in mice was mainly mediated by B cells and CD4+ T cells. Vaccinated, outbred guinea pigs and NHPs demonstrated the highest correlation between survival and levels of total immunoglobulin G (IgG) specific to the ZEBOV glycoprotein (ZGP). These results highlight the relevance of total ZGP-specific IgG levels as a meaningful correlate of protection against ZEBOV exposure.

Original languageEnglish (US)
Article number158ra146
JournalScience Translational Medicine
Volume4
Issue number158
DOIs
StatePublished - Oct 31 2012
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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