Immune response among patients exposed to molds

David A. Edmondson, Christy S. Barrios, Trevor L. Brasel, David C. Straus, Viswanath P. Kurup, Jordan N. Fink

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Macrocyclic trichothecenes, mycotoxins produced by Stachybotrys chartarum, have been implicated in adverse reactions in individuals exposed to mold-contaminated environments. Cellular and humoral immune responses and the presence of trichothecenes were evaluated in patients with mold-related health complaints. Patients underwent history, physical examination, skin prick/puncture tests with mold extracts, immunological evaluations and their sera were analyzed for trichothecenes. T-cell proliferation, macrocyclic trichothecenes, and mold specific IgG and IgA levels were not significantly different than controls; however 70% of the patients had positive skin tests to molds. Thus, IgE mediated or other non-immune mechanisms could be the cause of their symptoms.

Original languageEnglish (US)
Pages (from-to)5471-5484
Number of pages14
JournalInternational Journal of Molecular Sciences
Volume10
Issue number12
DOIs
StatePublished - Dec 2009
Externally publishedYes

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Keywords

  • Clinical symptoms
  • Immune response
  • Molds
  • Mycotoxins

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Edmondson, D. A., Barrios, C. S., Brasel, T. L., Straus, D. C., Kurup, V. P., & Fink, J. N. (2009). Immune response among patients exposed to molds. International Journal of Molecular Sciences, 10(12), 5471-5484. https://doi.org/10.3390/ijms10125471