Immune response among patients exposed to molds

David A. Edmondson; Christy S. Barrios; Trevor L. Brasel; David C. Straus; Viswanath P. Kurup; Jordan N. Fink

doi:10.3390/ijms10125471

Immune response among patients exposed to molds

David A. Edmondson
, Christy S. Barrios
, Trevor L. Brasel
, David C. Straus
, Viswanath P. Kurup
, Jordan N. Fink

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Macrocyclic trichothecenes, mycotoxins produced by Stachybotrys chartarum, have been implicated in adverse reactions in individuals exposed to mold-contaminated environments. Cellular and humoral immune responses and the presence of trichothecenes were evaluated in patients with mold-related health complaints. Patients underwent history, physical examination, skin prick/puncture tests with mold extracts, immunological evaluations and their sera were analyzed for trichothecenes. T-cell proliferation, macrocyclic trichothecenes, and mold specific IgG and IgA levels were not significantly different than controls; however 70% of the patients had positive skin tests to molds. Thus, IgE mediated or other non-immune mechanisms could be the cause of their symptoms.

Original language	English (US)
Pages (from-to)	5471-5484
Number of pages	14
Journal	International journal of molecular sciences
Volume	10
Issue number	12
DOIs	https://doi.org/10.3390/ijms10125471
State	Published - Dec 2009
Externally published	Yes

Keywords

Clinical symptoms
Immune response
Molds
Mycotoxins

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms10125471

Cite this

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title = "Immune response among patients exposed to molds",

abstract = "Macrocyclic trichothecenes, mycotoxins produced by Stachybotrys chartarum, have been implicated in adverse reactions in individuals exposed to mold-contaminated environments. Cellular and humoral immune responses and the presence of trichothecenes were evaluated in patients with mold-related health complaints. Patients underwent history, physical examination, skin prick/puncture tests with mold extracts, immunological evaluations and their sera were analyzed for trichothecenes. T-cell proliferation, macrocyclic trichothecenes, and mold specific IgG and IgA levels were not significantly different than controls; however 70\% of the patients had positive skin tests to molds. Thus, IgE mediated or other non-immune mechanisms could be the cause of their symptoms.",

keywords = "Clinical symptoms, Immune response, Molds, Mycotoxins",

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language = "English (US)",

volume = "10",

pages = "5471--5484",

journal = "International journal of molecular sciences",

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T1 - Immune response among patients exposed to molds

AU - Edmondson, David A.

AU - Barrios, Christy S.

AU - Brasel, Trevor L.

AU - Straus, David C.

AU - Kurup, Viswanath P.

AU - Fink, Jordan N.

PY - 2009/12

Y1 - 2009/12

N2 - Macrocyclic trichothecenes, mycotoxins produced by Stachybotrys chartarum, have been implicated in adverse reactions in individuals exposed to mold-contaminated environments. Cellular and humoral immune responses and the presence of trichothecenes were evaluated in patients with mold-related health complaints. Patients underwent history, physical examination, skin prick/puncture tests with mold extracts, immunological evaluations and their sera were analyzed for trichothecenes. T-cell proliferation, macrocyclic trichothecenes, and mold specific IgG and IgA levels were not significantly different than controls; however 70% of the patients had positive skin tests to molds. Thus, IgE mediated or other non-immune mechanisms could be the cause of their symptoms.

AB - Macrocyclic trichothecenes, mycotoxins produced by Stachybotrys chartarum, have been implicated in adverse reactions in individuals exposed to mold-contaminated environments. Cellular and humoral immune responses and the presence of trichothecenes were evaluated in patients with mold-related health complaints. Patients underwent history, physical examination, skin prick/puncture tests with mold extracts, immunological evaluations and their sera were analyzed for trichothecenes. T-cell proliferation, macrocyclic trichothecenes, and mold specific IgG and IgA levels were not significantly different than controls; however 70% of the patients had positive skin tests to molds. Thus, IgE mediated or other non-immune mechanisms could be the cause of their symptoms.

KW - Clinical symptoms

KW - Immune response

KW - Molds

KW - Mycotoxins

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U2 - 10.3390/ijms10125471

DO - 10.3390/ijms10125471

M3 - Article

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AN - SCOPUS:74249098660

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EP - 5484

JO - International journal of molecular sciences

JF - International journal of molecular sciences

IS - 12

ER -

Immune response among patients exposed to molds

Abstract

Keywords

ASJC Scopus subject areas

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