Immune response and protective efficacy against homologous challenge in BALB/c mice vaccinated with DNA vaccine encoding Toxoplasma gondii actin depolymerizing factor gene

Jianhua Li, Xiangsheng Huang, Guocai Zhang, Pengtao Gong, Xichen Zhang, Ling Wu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A DNA vaccine (pVAX1-TgADF) encoding Toxoplasma gondii actin depolymerizing factor (ADF) gene was constructed and the immune response and protective efficacy of this vaccine against homologous challenge in BALB/c mice were evaluated. High titers of specific antibody and increases in the percentage of CD4+ and CD8+ T lymphocyte cells were observed from BALB/c mice vaccinated with pVAX1-TgADF (P

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalVeterinary Parasitology
Volume179
Issue number1-3
DOIs
StatePublished - Jun 30 2011
Externally publishedYes

Fingerprint

Destrin
DNA Vaccines
Toxoplasma
recombinant vaccines
Toxoplasma gondii
actin
immune response
mice
Genes
Vaccines
genes
T-lymphocytes
vaccines
T-Lymphocytes
antibodies
Antibodies
cells

Keywords

  • Actin depolymerizing factor
  • BALB/c mice
  • DNA vaccine
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)

Cite this

Immune response and protective efficacy against homologous challenge in BALB/c mice vaccinated with DNA vaccine encoding Toxoplasma gondii actin depolymerizing factor gene. / Li, Jianhua; Huang, Xiangsheng; Zhang, Guocai; Gong, Pengtao; Zhang, Xichen; Wu, Ling.

In: Veterinary Parasitology, Vol. 179, No. 1-3, 30.06.2011, p. 1-6.

Research output: Contribution to journalArticle

Li, Jianhua ; Huang, Xiangsheng ; Zhang, Guocai ; Gong, Pengtao ; Zhang, Xichen ; Wu, Ling. / Immune response and protective efficacy against homologous challenge in BALB/c mice vaccinated with DNA vaccine encoding Toxoplasma gondii actin depolymerizing factor gene. In: Veterinary Parasitology. 2011 ; Vol. 179, No. 1-3. pp. 1-6.
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