Immune response and protective efficacy against homologous challenge in BALB/c mice vaccinated with DNA vaccine encoding Toxoplasma gondii actin depolymerizing factor gene

Jianhua Li, Xiangsheng Huang, Guocai Zhang, Pengtao Gong, Xichen Zhang, Ling Wu

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A DNA vaccine (pVAX1-TgADF) encoding Toxoplasma gondii actin depolymerizing factor (ADF) gene was constructed and the immune response and protective efficacy of this vaccine against homologous challenge in BALB/c mice were evaluated. High titers of specific antibody and increases in the percentage of CD4+ and CD8+ T lymphocyte cells were observed from BALB/c mice vaccinated with pVAX1-TgADF (P

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalVeterinary Parasitology
Volume179
Issue number1-3
DOIs
StatePublished - Jun 30 2011
Externally publishedYes

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Keywords

  • Actin depolymerizing factor
  • BALB/c mice
  • DNA vaccine
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)

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