Immune response gene control of lymphocyte proliferation induced by acetylcholine receptor-specific helper factor derived from lymphocytes of myasthenic mice

P. Christadoss, J. M. Lindstrom, N. Talal, C. R. Duvic, A. Kalantri, M. Shenoy

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The role of lymphokines secreted by acetylcholine receptor (AChR)-reactive lymphocytes in the regulation of an autoimmune response to AChR has not been studied in the human or murine model of myasthenia gravis. We investigated whether AChR-immune lymphocytes derived from mice with experimental autoimmune myasthenia gravis (EAMG) can produce an AChR-specific, genetically controlled soluble factor with biologic activity. AChR-reactive lymphocytes of mice with EAMG secreted an AChR-specific helper factor in vitro, which induced proliferation of AChR-immune but not Mycobacterium tuberculosis-immune lymphocytes. Recombinant, I-A mutant, and monoclonal anti-I-A antibody analyses suggest that AChR-specific helper factor-induced lymphocyte proliferation is controlled by an immune response gene at the I-A subregion of the murine major histocompatibility complex, and is mediated by the I-A molecule.

Original languageEnglish (US)
Pages (from-to)1845-1849
Number of pages5
JournalJournal of Immunology
Volume137
Issue number6
StatePublished - 1986
Externally publishedYes

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Muscle Weakness
Cholinergic Receptors
Lymphocytes
Genes
Autoimmune Experimental Myasthenia Gravis
Lymphokines
Myasthenia Gravis
Biological Factors
Major Histocompatibility Complex
Autoimmunity
Mycobacterium tuberculosis
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Immune response gene control of lymphocyte proliferation induced by acetylcholine receptor-specific helper factor derived from lymphocytes of myasthenic mice. / Christadoss, P.; Lindstrom, J. M.; Talal, N.; Duvic, C. R.; Kalantri, A.; Shenoy, M.

In: Journal of Immunology, Vol. 137, No. 6, 1986, p. 1845-1849.

Research output: Contribution to journalArticle

Christadoss, P, Lindstrom, JM, Talal, N, Duvic, CR, Kalantri, A & Shenoy, M 1986, 'Immune response gene control of lymphocyte proliferation induced by acetylcholine receptor-specific helper factor derived from lymphocytes of myasthenic mice', Journal of Immunology, vol. 137, no. 6, pp. 1845-1849.
Christadoss, P. ; Lindstrom, J. M. ; Talal, N. ; Duvic, C. R. ; Kalantri, A. ; Shenoy, M. / Immune response gene control of lymphocyte proliferation induced by acetylcholine receptor-specific helper factor derived from lymphocytes of myasthenic mice. In: Journal of Immunology. 1986 ; Vol. 137, No. 6. pp. 1845-1849.
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