Immune response gene control of lymphocyte proliferation induced by acetylcholine receptor-specific helper factor derived from lymphocytes of myasthenic mice

P. Christadoss, J. M. Lindstrom, N. Talal, C. R. Duvic, A. Kalantri, M. Shenoy

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The role of lymphokines secreted by acetylcholine receptor (AChR)-reactive lymphocytes in the regulation of an autoimmune response to AChR has not been studied in the human or murine model of myasthenia gravis. We investigated whether AChR-immune lymphocytes derived from mice with experimental autoimmune myasthenia gravis (EAMG) can produce an AChR-specific, genetically controlled soluble factor with biologic activity. AChR-reactive lymphocytes of mice with EAMG secreted an AChR-specific helper factor in vitro, which induced proliferation of AChR-immune but not Mycobacterium tuberculosis-immune lymphocytes. Recombinant, I-A mutant, and monoclonal anti-I-A antibody analyses suggest that AChR-specific helper factor-induced lymphocyte proliferation is controlled by an immune response gene at the I-A subregion of the murine major histocompatibility complex, and is mediated by the I-A molecule.

Original languageEnglish (US)
Pages (from-to)1845-1849
Number of pages5
JournalJournal of Immunology
Volume137
Issue number6
StatePublished - Nov 26 1986

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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