Immune response to H pylori

Giovanni Suarez, Victor E. Reyes, Ellen J. Beswick

Research output: Contribution to journalEditorial

32 Scopus citations

Abstract

The gastric mucosa separates the underlying tissue from the vast array of antigens that traffic through the stomach lumen. While extreme pH of this environment is essential in aiding the activation of enzymes and food digestion, it also renders the gastric epithelium free from bacterial colonization, with the exception of one important human pathogen, H pylori. This bacterium has developed mechanisms to survive the harsh environment of the stomach, actively move through the mucosal layer, attach to the epithelium, evade immune responses, and achieve persistent colonization. While a hallmark of this infection is a marked inflammatory response with the infiltration of various immune cells into the infected gastric mucosa, the host immune response is unable to clear the infection and may actually contribute to the associated pathogenesis. Here, we review the host responses involved during infection with H pylori and how they are influenced by this bacterium.

Original languageEnglish (US)
Pages (from-to)5593-5598
Number of pages6
JournalWorld journal of gastroenterology
Volume12
Issue number35
DOIs
StatePublished - Sep 21 2006

Keywords

  • Dendritic
  • H pylori
  • Immune response
  • T cell

ASJC Scopus subject areas

  • Gastroenterology

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