Immunity to West Nile virus

Tian Wang, Erol Fikrig

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Over the past five years, West Nile (WN) virus has emerged as an important public health concern in the United States. Recent studies from experimental models of WN virus infection have increased our understanding of its pathogenesis and immunity. These include the demonstration that the gene encoding 2′-5′oligoadenylate synthetase is responsible for murine susceptibility to WN virus, the elucidation of the contributions of B, CD8 + and γ T cells in the control of murine WN virus infection, and the use of active immunization with envelope protein and passive transfer of immunoglobulin for immunotherapy. These efforts will facilitate the development of effective vaccines and therapies to combat WN virus.

Original languageEnglish (US)
Pages (from-to)519-523
Number of pages5
JournalCurrent Opinion in Immunology
Volume16
Issue number4
DOIs
StatePublished - Aug 2004
Externally publishedYes

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Keywords

  • antigen-presenting cell
  • APC
  • central nervous system
  • CNS
  • DEN4
  • dengue virus type 4
  • E
  • envelope
  • IFN
  • interferon
  • intravenous immunoglobulin
  • IVIG
  • M
  • membrane
  • OAS
  • oligoadenylate synthetase
  • West Nile
  • WN

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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