Immunization strategies against henipaviruses

Christopher C. Broder, Thomas Geisbert, Kai Xu, Dimitar B. Nikolov, Lin Fa Wang, Deborah Middleton, Jackie Pallister, Katharine N. Bossart

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)

Abstract

Hendra virus and Nipah virus are recently discovered and closely related emerging viruses that now comprise the genus henipavirus within the sub-family Paramyxoviridae and are distinguished by their broad species tropism and in addition to bats can infect and cause fatal disease in a wide variety of mammalian hosts including humans. The high mortality associated with human and animal henipavirus infections has highlighted the importance and necessity of developing effective immunization strategies. The development of suitable animal models of henipavirus infection and pathogenesis has been critical for testing the efficacy of potential therapeutic approaches. Several henipavirus challenge models have been used and recent successes in both active and passive immunization strategies against henipaviruses have been reported which have all targeted the viral envelope glycoproteins.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Microbiology and Immunology
Pages197-223
Number of pages27
Volume359
DOIs
StatePublished - 2012

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume359
ISSN (Print)0070217X

Fingerprint

Henipavirus
Henipavirus Infections
Immunization
Hendra Virus
Paramyxoviridae
Nipah Virus
Tropism
Passive Immunization
Glycoproteins
Vaccination
Animal Models
Viruses
Mortality
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology
  • Microbiology

Cite this

Broder, C. C., Geisbert, T., Xu, K., Nikolov, D. B., Wang, L. F., Middleton, D., ... Bossart, K. N. (2012). Immunization strategies against henipaviruses. In Current Topics in Microbiology and Immunology (Vol. 359, pp. 197-223). (Current Topics in Microbiology and Immunology; Vol. 359). https://doi.org/10.1007/82-2012-213

Immunization strategies against henipaviruses. / Broder, Christopher C.; Geisbert, Thomas; Xu, Kai; Nikolov, Dimitar B.; Wang, Lin Fa; Middleton, Deborah; Pallister, Jackie; Bossart, Katharine N.

Current Topics in Microbiology and Immunology. Vol. 359 2012. p. 197-223 (Current Topics in Microbiology and Immunology; Vol. 359).

Research output: Chapter in Book/Report/Conference proceedingChapter

Broder, CC, Geisbert, T, Xu, K, Nikolov, DB, Wang, LF, Middleton, D, Pallister, J & Bossart, KN 2012, Immunization strategies against henipaviruses. in Current Topics in Microbiology and Immunology. vol. 359, Current Topics in Microbiology and Immunology, vol. 359, pp. 197-223. https://doi.org/10.1007/82-2012-213
Broder CC, Geisbert T, Xu K, Nikolov DB, Wang LF, Middleton D et al. Immunization strategies against henipaviruses. In Current Topics in Microbiology and Immunology. Vol. 359. 2012. p. 197-223. (Current Topics in Microbiology and Immunology). https://doi.org/10.1007/82-2012-213
Broder, Christopher C. ; Geisbert, Thomas ; Xu, Kai ; Nikolov, Dimitar B. ; Wang, Lin Fa ; Middleton, Deborah ; Pallister, Jackie ; Bossart, Katharine N. / Immunization strategies against henipaviruses. Current Topics in Microbiology and Immunology. Vol. 359 2012. pp. 197-223 (Current Topics in Microbiology and Immunology).
@inbook{191d307b039c4991a76cdd4d78d7ebc1,
title = "Immunization strategies against henipaviruses",
abstract = "Hendra virus and Nipah virus are recently discovered and closely related emerging viruses that now comprise the genus henipavirus within the sub-family Paramyxoviridae and are distinguished by their broad species tropism and in addition to bats can infect and cause fatal disease in a wide variety of mammalian hosts including humans. The high mortality associated with human and animal henipavirus infections has highlighted the importance and necessity of developing effective immunization strategies. The development of suitable animal models of henipavirus infection and pathogenesis has been critical for testing the efficacy of potential therapeutic approaches. Several henipavirus challenge models have been used and recent successes in both active and passive immunization strategies against henipaviruses have been reported which have all targeted the viral envelope glycoproteins.",
author = "Broder, {Christopher C.} and Thomas Geisbert and Kai Xu and Nikolov, {Dimitar B.} and Wang, {Lin Fa} and Deborah Middleton and Jackie Pallister and Bossart, {Katharine N.}",
year = "2012",
doi = "10.1007/82-2012-213",
language = "English (US)",
isbn = "9783642298189",
volume = "359",
series = "Current Topics in Microbiology and Immunology",
pages = "197--223",
booktitle = "Current Topics in Microbiology and Immunology",

}

TY - CHAP

T1 - Immunization strategies against henipaviruses

AU - Broder, Christopher C.

AU - Geisbert, Thomas

AU - Xu, Kai

AU - Nikolov, Dimitar B.

AU - Wang, Lin Fa

AU - Middleton, Deborah

AU - Pallister, Jackie

AU - Bossart, Katharine N.

PY - 2012

Y1 - 2012

N2 - Hendra virus and Nipah virus are recently discovered and closely related emerging viruses that now comprise the genus henipavirus within the sub-family Paramyxoviridae and are distinguished by their broad species tropism and in addition to bats can infect and cause fatal disease in a wide variety of mammalian hosts including humans. The high mortality associated with human and animal henipavirus infections has highlighted the importance and necessity of developing effective immunization strategies. The development of suitable animal models of henipavirus infection and pathogenesis has been critical for testing the efficacy of potential therapeutic approaches. Several henipavirus challenge models have been used and recent successes in both active and passive immunization strategies against henipaviruses have been reported which have all targeted the viral envelope glycoproteins.

AB - Hendra virus and Nipah virus are recently discovered and closely related emerging viruses that now comprise the genus henipavirus within the sub-family Paramyxoviridae and are distinguished by their broad species tropism and in addition to bats can infect and cause fatal disease in a wide variety of mammalian hosts including humans. The high mortality associated with human and animal henipavirus infections has highlighted the importance and necessity of developing effective immunization strategies. The development of suitable animal models of henipavirus infection and pathogenesis has been critical for testing the efficacy of potential therapeutic approaches. Several henipavirus challenge models have been used and recent successes in both active and passive immunization strategies against henipaviruses have been reported which have all targeted the viral envelope glycoproteins.

UR - http://www.scopus.com/inward/record.url?scp=84864879265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864879265&partnerID=8YFLogxK

U2 - 10.1007/82-2012-213

DO - 10.1007/82-2012-213

M3 - Chapter

SN - 9783642298189

VL - 359

T3 - Current Topics in Microbiology and Immunology

SP - 197

EP - 223

BT - Current Topics in Microbiology and Immunology

ER -