Immunization strategies against henipaviruses

Christopher C. Broder, Thomas W. Geisbert, Kai Xu, Dimitar B. Nikolov, Lin Fa Wang, Deborah Middleton, Jackie Pallister, Katharine N. Bossart

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Abstract

Hendra virus and Nipah virus are recently discovered and closely related emerging viruses that now comprise the genus henipavirus within the sub-family Paramyxoviridae and are distinguished by their broad species tropism and in addition to bats can infect and cause fatal disease in a wide variety of mammalian hosts including humans. The high mortality associated with human and animal henipavirus infections has highlighted the importance and necessity of developing effective immunization strategies. The development of suitable animal models of henipavirus infection and pathogenesis has been critical for testing the efficacy of potential therapeutic approaches. Several henipavirus challenge models have been used and recent successes in both active and passive immunization strategies against henipaviruses have been reported which have all targeted the viral envelope glycoproteins.

Original languageEnglish (US)
Title of host publicationHenipavirus
Subtitle of host publicationEcology, Molecular Virology, and Pathogenesis
EditorsBenhur Lee, Paul Rota
Pages197-223
Number of pages27
DOIs
StatePublished - Nov 8 2012

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume359
ISSN (Print)0070-217X

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

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  • Cite this

    Broder, C. C., Geisbert, T. W., Xu, K., Nikolov, D. B., Wang, L. F., Middleton, D., Pallister, J., & Bossart, K. N. (2012). Immunization strategies against henipaviruses. In B. Lee, & P. Rota (Eds.), Henipavirus: Ecology, Molecular Virology, and Pathogenesis (pp. 197-223). (Current Topics in Microbiology and Immunology; Vol. 359). https://doi.org/10.1007/82-2012-213