Immunization with heterologous flaviviruses protective against fatal west Nile encephalitis

Robert B. Tesh, Amelia P A Travassos da Rosa, Hilda Guzman, Tais P. Araujo, Shu Yuan Xiao

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Prior immunization of hamsters with three heterologous fiaviviruses (Japanese encephalitis virus [JEV] SA14-2-8 vaccine, wild-type St. Louis encephalitis virus [SLEV], and Yellow fever virus [YFV] 17D vaccine) reduces the severity of subsequent West Nile virus (WNV) infection. Groups of adult hamsters were immunized with each of the heterologous flaviviruses; approximately 30 days later, the animals were injected intraperitoneally with a virulent New York strain of WNV. Subsequent levels of viremia, antibody response, and deaths were compared with those in nonimmune (control) hamsters. Immunity to JEV and SLEV was protective against clinical encephalitis and death after challenge with WNV. The antibody response in the sequentially infected hamsters also illustrates the difficulty in making a serologic diagnosis of WNV infection in animals (or humans) with preexisting Flavivirus immunity.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalEmerging Infectious Diseases
Volume8
Issue number3
StatePublished - 2002

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Flavivirus
West Nile virus
Encephalitis
Cricetinae
Japanese Encephalitis Virus
Immunization
St. Louis Encephalitis Viruses
Virus Diseases
Antibody Formation
Immunity
Vaccines
Yellow fever virus
Viremia

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Tesh, R. B., Travassos da Rosa, A. P. A., Guzman, H., Araujo, T. P., & Xiao, S. Y. (2002). Immunization with heterologous flaviviruses protective against fatal west Nile encephalitis. Emerging Infectious Diseases, 8(3), 245-251.

Immunization with heterologous flaviviruses protective against fatal west Nile encephalitis. / Tesh, Robert B.; Travassos da Rosa, Amelia P A; Guzman, Hilda; Araujo, Tais P.; Xiao, Shu Yuan.

In: Emerging Infectious Diseases, Vol. 8, No. 3, 2002, p. 245-251.

Research output: Contribution to journalArticle

Tesh, RB, Travassos da Rosa, APA, Guzman, H, Araujo, TP & Xiao, SY 2002, 'Immunization with heterologous flaviviruses protective against fatal west Nile encephalitis', Emerging Infectious Diseases, vol. 8, no. 3, pp. 245-251.
Tesh RB, Travassos da Rosa APA, Guzman H, Araujo TP, Xiao SY. Immunization with heterologous flaviviruses protective against fatal west Nile encephalitis. Emerging Infectious Diseases. 2002;8(3):245-251.
Tesh, Robert B. ; Travassos da Rosa, Amelia P A ; Guzman, Hilda ; Araujo, Tais P. ; Xiao, Shu Yuan. / Immunization with heterologous flaviviruses protective against fatal west Nile encephalitis. In: Emerging Infectious Diseases. 2002 ; Vol. 8, No. 3. pp. 245-251.
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