Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus

Anurodh Shankar Agrawal, Xinrong Tao, Abdullah Algaissi, Tania Garron, Krishna Narayanan, Bihung Peng, Robert B. Couch, Chien-Te Tseng

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

To determine if a hypersensitive-type lung pathology might occur when mice were given an inactivated MERS-CoV vaccine and challenged with infectious virus as was seen with SARS-CoV vaccines, we prepared and vaccinated mice with an inactivated MERS-CoV vaccine. Neutralizing antibody was induced by vaccine with and without adjuvant and lung virus was reduced in vaccinated mice after challenge. Lung mononuclear infiltrates occurred in all groups after virus challenge but with increased infiltrates that contained eosinophils and increases in the eosinophil promoting IL-5 and IL-13 cytokines only in the vaccine groups. Inactivated MERS-CoV vaccine appears to carry a hypersensitive-type lung pathology risk from MERS-CoV infection that is similar to that found with inactivated SARS-CoV vaccines from SARS-CoV infection.

Original languageEnglish (US)
Pages (from-to)2351-2356
Number of pages6
JournalHuman Vaccines and Immunotherapeutics
Volume12
Issue number9
DOIs
StatePublished - Sep 1 2016

Fingerprint

Immunization
Vaccines
Viruses
Lung
SARS Virus
Eosinophils
Pathology
Interleukin-13
Interleukin-5
Infection
Middle East Respiratory Syndrome Coronavirus
Neutralizing Antibodies
Cytokines

Keywords

  • coronavirus; Eosinophils; immunopathology; Middle East Respiratory Syndrome; vaccination

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus. / Agrawal, Anurodh Shankar; Tao, Xinrong; Algaissi, Abdullah; Garron, Tania; Narayanan, Krishna; Peng, Bihung; Couch, Robert B.; Tseng, Chien-Te.

In: Human Vaccines and Immunotherapeutics, Vol. 12, No. 9, 01.09.2016, p. 2351-2356.

Research output: Contribution to journalArticle

Agrawal, Anurodh Shankar ; Tao, Xinrong ; Algaissi, Abdullah ; Garron, Tania ; Narayanan, Krishna ; Peng, Bihung ; Couch, Robert B. ; Tseng, Chien-Te. / Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus. In: Human Vaccines and Immunotherapeutics. 2016 ; Vol. 12, No. 9. pp. 2351-2356.
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