Immunodeficiency of aging

Edith A. Burns, James Goodwin

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Aging is associated with declines in multiple areas of immune function, but to date no single mechanism has emerged as being responsible for all the observed changes. Many changes occur at different rates within individuals as well as between individuals. With advancing age there is a concomitant increase in the incidence of many infections and cancers. It is bring increasingly acknowledged that autoimmune processes play a proinflammatory role in the development of many pathological conditions, such as atherosclerosis. However, direct causal relationships between specific changes in immunity and the occurrence of specific diseases are rare. Then is accumulating epidemiological, in vivo and in vitro evidence to support many such direct relationships in both animals and humans. It is likely that the mechanisms underlying age-related changes in immunity are multifactorial, with both genetic and environmental factors playing a significant role. Despite the current lack of unifying theories, much active and exciting work is proceeding in the area of immune stimulation. Studies describing age-related changes in immunity, as well as the testing of interventions to reverse these changes, will continue to fill the gaps in our knowledge, leading to a more comprehensive understanding of immunosenescence.

Original languageEnglish (US)
Pages (from-to)374-397
Number of pages24
JournalDrugs and Aging
Volume11
Issue number5
StatePublished - Nov 1997

Fingerprint

Immunity
Rare Diseases
Atherosclerosis
Incidence
Infection
Neoplasms
Immunosenescence
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology
  • Geriatrics and Gerontology

Cite this

Burns, E. A., & Goodwin, J. (1997). Immunodeficiency of aging. Drugs and Aging, 11(5), 374-397.

Immunodeficiency of aging. / Burns, Edith A.; Goodwin, James.

In: Drugs and Aging, Vol. 11, No. 5, 11.1997, p. 374-397.

Research output: Contribution to journalArticle

Burns, EA & Goodwin, J 1997, 'Immunodeficiency of aging', Drugs and Aging, vol. 11, no. 5, pp. 374-397.
Burns EA, Goodwin J. Immunodeficiency of aging. Drugs and Aging. 1997 Nov;11(5):374-397.
Burns, Edith A. ; Goodwin, James. / Immunodeficiency of aging. In: Drugs and Aging. 1997 ; Vol. 11, No. 5. pp. 374-397.
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