Abstract
The specificity of a single rabbit antiserum pool raised against the purified major glycoprotein, gp71, of Friend murine leukemia virus was determined for a variety of virus producing mouse, feline, and gibbon ape cell lines by viable cell membrane immunofluorescence absorption. Among murine cells examined, Friend gp71 type specificity was shared only with Rauscher virus producing cells, and a group specificity was present for all the murine leukemia virus producing cells tested. Friend and Rauscher murine leukemia virus infected cells shared interspecies crossreactivity with feline leukemia and gibbon ape lymphoma virus producing cells. However, Moloney, Gross, and other virus producing murine cells shared some, but not all, of these gp71 interspecies determinants with the feline and primate cells. Immunoferritin electron microscopy localized these gp71 antigenic determinants on both virus and cells membranes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 922-930 |
| Number of pages | 9 |
| Journal | Cancer Research |
| Volume | 37 |
| Issue number | 3 |
| State | Published - 1977 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Immunofluorescent analysis of expression of the RNA tumor virus major glycoprotein, gp71, on surfaces of virus producing murine and other mammalian species cell lines. / Cloyd, M. W.; Bolognesi, D. P.; Bigner, D. D.
In: Cancer Research, Vol. 37, No. 3, 1977, p. 922-930.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunofluorescent analysis of expression of the RNA tumor virus major glycoprotein, gp71, on surfaces of virus producing murine and other mammalian species cell lines
AU - Cloyd, M. W.
AU - Bolognesi, D. P.
AU - Bigner, D. D.
PY - 1977
Y1 - 1977
N2 - The specificity of a single rabbit antiserum pool raised against the purified major glycoprotein, gp71, of Friend murine leukemia virus was determined for a variety of virus producing mouse, feline, and gibbon ape cell lines by viable cell membrane immunofluorescence absorption. Among murine cells examined, Friend gp71 type specificity was shared only with Rauscher virus producing cells, and a group specificity was present for all the murine leukemia virus producing cells tested. Friend and Rauscher murine leukemia virus infected cells shared interspecies crossreactivity with feline leukemia and gibbon ape lymphoma virus producing cells. However, Moloney, Gross, and other virus producing murine cells shared some, but not all, of these gp71 interspecies determinants with the feline and primate cells. Immunoferritin electron microscopy localized these gp71 antigenic determinants on both virus and cells membranes.
AB - The specificity of a single rabbit antiserum pool raised against the purified major glycoprotein, gp71, of Friend murine leukemia virus was determined for a variety of virus producing mouse, feline, and gibbon ape cell lines by viable cell membrane immunofluorescence absorption. Among murine cells examined, Friend gp71 type specificity was shared only with Rauscher virus producing cells, and a group specificity was present for all the murine leukemia virus producing cells tested. Friend and Rauscher murine leukemia virus infected cells shared interspecies crossreactivity with feline leukemia and gibbon ape lymphoma virus producing cells. However, Moloney, Gross, and other virus producing murine cells shared some, but not all, of these gp71 interspecies determinants with the feline and primate cells. Immunoferritin electron microscopy localized these gp71 antigenic determinants on both virus and cells membranes.
UR - http://www.scopus.com/inward/record.url?scp=0017689227&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017689227&partnerID=8YFLogxK
M3 - Article
VL - 37
SP - 922
EP - 930
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 3
ER -