Abstract
Growth of the chemically induced, transplantable rat brain tumor gliosarcoma 9L (GS-9L) is under immunogenetic control. Both susceptible and resistant rats produce an immune response to the tumor, but the response is qualitatively different in the two groups. The intraperitoneal administration of gliosarcoma-9L cells in resistant KGH rats causes the production of cytotoxic lymphocytes and macrophages, and in susceptible F344 rats suppressor lymphocytes are produced. After gliosarcoma-9L cells were administered to (KGH x F344)F1 and backcross rats, tumor susceptibility or resistance and the nature of the immune response correlated well with the histocompatibility type, indicating the parallel genetic control of both traits. However, a second gene or gene complex, not linked to the major histocompatibility complex, may participate in the regulation of tumor growth.
Original language | English (US) |
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Pages (from-to) | 436-444 |
Number of pages | 9 |
Journal | Laboratory Investigation |
Volume | 49 |
Issue number | 4 |
State | Published - 1983 |
Externally published | Yes |
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Biology
- Cell Biology