TY - JOUR
T1 - Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle
AU - Paran, Nir
AU - Wirblich, Christoph
AU - Olal, Catherine
AU - Tarquinio, Alessandro
AU - Lohmeyer, Kimberly H.
AU - Kurup, Drishya
AU - Schultz-Cherry, Stacey
AU - Shittu, Ismaila
AU - Gray, Gregory C.
AU - Bente, Dennis A.
AU - Olafson, Pia U.
AU - Schnell, Matthias J.
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/12
Y1 - 2025/12
N2 - The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based H5 vaccine, which was well-tolerated and elicited neutralizing antibodies against both clade-1 and clade-2.3.4.4b H5N1 viruses, comparable to naturally H5-infected and convalescing cows. The immune responses to the vaccine platform were durable for at least 200 days and unaffected by preexisting RABV immunity.
AB - The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based H5 vaccine, which was well-tolerated and elicited neutralizing antibodies against both clade-1 and clade-2.3.4.4b H5N1 viruses, comparable to naturally H5-infected and convalescing cows. The immune responses to the vaccine platform were durable for at least 200 days and unaffected by preexisting RABV immunity.
UR - https://www.scopus.com/pages/publications/105013557991
UR - https://www.scopus.com/inward/citedby.url?scp=105013557991&partnerID=8YFLogxK
U2 - 10.1038/s41541-025-01238-2
DO - 10.1038/s41541-025-01238-2
M3 - Article
C2 - 40830096
AN - SCOPUS:105013557991
SN - 2059-0105
VL - 10
JO - npj Vaccines
JF - npj Vaccines
IS - 1
M1 - 197
ER -