Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle

Nir Paran; Christoph Wirblich; Catherine Olal; Alessandro Tarquinio; Kimberly H. Lohmeyer; Drishya Kurup; Stacey Schultz-Cherry; Ismaila Shittu; Gregory C. Gray; Dennis A. Bente; Pia U. Olafson; Matthias J. Schnell

doi:10.1038/s41541-025-01238-2

Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle

Nir Paran
, Christoph Wirblich
, Catherine Olal
, Alessandro Tarquinio
, Kimberly H. Lohmeyer
, Drishya Kurup
, Stacey Schultz-Cherry
, Ismaila Shittu
, Gregory C. Gray
, Dennis A. Bente
, Pia U. Olafson
, Matthias J. Schnell

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based H5 vaccine, which was well-tolerated and elicited neutralizing antibodies against both clade-1 and clade-2.3.4.4b H5N1 viruses, comparable to naturally H5-infected and convalescing cows. The immune responses to the vaccine platform were durable for at least 200 days and unaffected by preexisting RABV immunity.

Original language	English (US)
Article number	197
Journal	npj Vaccines
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41541-025-01238-2
State	Published - Dec 2025

ASJC Scopus subject areas

Immunology
Pharmacology
Infectious Diseases
Pharmacology (medical)

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10.1038/s41541-025-01238-2

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title = "Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle",

abstract = "The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based H5 vaccine, which was well-tolerated and elicited neutralizing antibodies against both clade-1 and clade-2.3.4.4b H5N1 viruses, comparable to naturally H5-infected and convalescing cows. The immune responses to the vaccine platform were durable for at least 200 days and unaffected by preexisting RABV immunity.",

author = "Nir Paran and Christoph Wirblich and Catherine Olal and Alessandro Tarquinio and Lohmeyer, \{Kimberly H.\} and Drishya Kurup and Stacey Schultz-Cherry and Ismaila Shittu and Gray, \{Gregory C.\} and Bente, \{Dennis A.\} and Olafson, \{Pia U.\} and Schnell, \{Matthias J.\}",

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doi = "10.1038/s41541-025-01238-2",

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AU - Paran, Nir

AU - Wirblich, Christoph

AU - Olal, Catherine

AU - Tarquinio, Alessandro

AU - Lohmeyer, Kimberly H.

AU - Kurup, Drishya

AU - Schultz-Cherry, Stacey

AU - Shittu, Ismaila

AU - Gray, Gregory C.

AU - Bente, Dennis A.

AU - Olafson, Pia U.

AU - Schnell, Matthias J.

PY - 2025/12

Y1 - 2025/12

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AB - The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based H5 vaccine, which was well-tolerated and elicited neutralizing antibodies against both clade-1 and clade-2.3.4.4b H5N1 viruses, comparable to naturally H5-infected and convalescing cows. The immune responses to the vaccine platform were durable for at least 200 days and unaffected by preexisting RABV immunity.

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ER -

Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle

Abstract

ASJC Scopus subject areas

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