Immunogenicity of the BA.1 and BA.4/BA.5 Severe Acute Respiratory Syndrome Coronavirus 2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial

Angela R. Branche; Nadine G. Rouphael; Cecilia Losada; Lindsey R. Baden; Evan J. Anderson; Anne F. Luetkemeyer; David J. Diemert; Patricia L. Winokur; Rachel M. Presti; Angelica C. Kottkamp; Ann R. Falsey; Sharon E. Frey; Richard Rupp; Martín Bäcker; Richard M. Novak; Emmanuel B. Walter; Lisa A. Jackson; Susan J. Little; Lilly C. Immergluck; Siham M. Mahgoub; Jennifer A. Whitaker; Tara M. Babu; Paul A. Goepfert; Dahlene N. Fusco; Robert L. Atmar; Christine M. Posavad; Antonia Netzl; Derek J. Smith; Kalyani Telu; Jinjian Mu; Mat Makowski; Mamodikoe K. Makhene; Sonja Crandon; David C. Montefiori; Paul C. Roberts; John H. Beigel

doi:10.1093/cid/ciad209

Immunogenicity of the BA.1 and BA.4/BA.5 Severe Acute Respiratory Syndrome Coronavirus 2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial

Angela R. Branche
, Nadine G. Rouphael
, Cecilia Losada
, Lindsey R. Baden
, Evan J. Anderson
, Anne F. Luetkemeyer
, David J. Diemert
, Patricia L. Winokur
, Rachel M. Presti
, Angelica C. Kottkamp
, Ann R. Falsey
, Sharon E. Frey
, Richard Rupp
, Martín Bäcker
, Richard M. Novak
, Emmanuel B. Walter
, Lisa A. Jackson
, Susan J. Little
, Lilly C. Immergluck
, Siham M. Mahgoub

Jennifer A. Whitaker, Tara M. Babu, Paul A. Goepfert, Dahlene N. Fusco, Robert L. Atmar, Christine M. Posavad, Antonia Netzl, Derek J. Smith, Kalyani Telu, Jinjian Mu, Mat Makowski, Mamodikoe K. Makhene, Sonja Crandon, David C. Montefiori, Paul C. Roberts, John H. Beigel

Pediatrics

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

In a randomized clinical trial, we compare early neutralizing antibody responses after boosting with bivalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccines based on either BA.1 or BA.4/BA.5 Omicron spike protein combined with wild-Type spike. Responses against SARS-CoV-2 variants exhibited the greatest reduction in titers against currently circulating Omicron subvariants for both bivalent vaccines.

Original language	English (US)
Pages (from-to)	560-564
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	77
Issue number	4
DOIs	https://doi.org/10.1093/cid/ciad209
State	Published - Aug 15 2023

Keywords

SARS-CoV-2
vaccine
variant

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Access to Document

10.1093/cid/ciad209

Cite this

Branche, A. R., Rouphael, N. G., Losada, C., Baden, L. R., Anderson, E. J., Luetkemeyer, A. F., Diemert, D. J., Winokur, P. L., Presti, R. M., Kottkamp, A. C., Falsey, A. R., Frey, S. E., Rupp, R., Bäcker, M., Novak, R. M., Walter, E. B., Jackson, L. A., Little, S. J., Immergluck, L. C., ... Beigel, J. H. (2023). Immunogenicity of the BA.1 and BA.4/BA.5 Severe Acute Respiratory Syndrome Coronavirus 2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial. Clinical Infectious Diseases, 77(4), 560-564. https://doi.org/10.1093/cid/ciad209

Immunogenicity of the BA.1 and BA.4/BA.5 Severe Acute Respiratory Syndrome Coronavirus 2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial. / Branche, Angela R.; Rouphael, Nadine G.; Losada, Cecilia et al.
In: Clinical Infectious Diseases, Vol. 77, No. 4, 15.08.2023, p. 560-564.

Research output: Contribution to journal › Article › peer-review

Branche, AR, Rouphael, NG, Losada, C, Baden, LR, Anderson, EJ, Luetkemeyer, AF, Diemert, DJ, Winokur, PL, Presti, RM, Kottkamp, AC, Falsey, AR, Frey, SE, Rupp, R, Bäcker, M, Novak, RM, Walter, EB, Jackson, LA, Little, SJ, Immergluck, LC, Mahgoub, SM, Whitaker, JA, Babu, TM, Goepfert, PA, Fusco, DN, Atmar, RL, Posavad, CM, Netzl, A, Smith, DJ, Telu, K, Mu, J, Makowski, M, Makhene, MK, Crandon, S, Montefiori, DC, Roberts, PC & Beigel, JH 2023, 'Immunogenicity of the BA.1 and BA.4/BA.5 Severe Acute Respiratory Syndrome Coronavirus 2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial', Clinical Infectious Diseases, vol. 77, no. 4, pp. 560-564. https://doi.org/10.1093/cid/ciad209

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title = "Immunogenicity of the BA.1 and BA.4/BA.5 Severe Acute Respiratory Syndrome Coronavirus 2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial",

abstract = "In a randomized clinical trial, we compare early neutralizing antibody responses after boosting with bivalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccines based on either BA.1 or BA.4/BA.5 Omicron spike protein combined with wild-Type spike. Responses against SARS-CoV-2 variants exhibited the greatest reduction in titers against currently circulating Omicron subvariants for both bivalent vaccines.",

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author = "Branche, \{Angela R.\} and Rouphael, \{Nadine G.\} and Cecilia Losada and Baden, \{Lindsey R.\} and Anderson, \{Evan J.\} and Luetkemeyer, \{Anne F.\} and Diemert, \{David J.\} and Winokur, \{Patricia L.\} and Presti, \{Rachel M.\} and Kottkamp, \{Angelica C.\} and Falsey, \{Ann R.\} and Frey, \{Sharon E.\} and Richard Rupp and Mart{\'i}n B{\"a}cker and Novak, \{Richard M.\} and Walter, \{Emmanuel B.\} and Jackson, \{Lisa A.\} and Little, \{Susan J.\} and Immergluck, \{Lilly C.\} and Mahgoub, \{Siham M.\} and Whitaker, \{Jennifer A.\} and Babu, \{Tara M.\} and Goepfert, \{Paul A.\} and Fusco, \{Dahlene N.\} and Atmar, \{Robert L.\} and Posavad, \{Christine M.\} and Antonia Netzl and Smith, \{Derek J.\} and Kalyani Telu and Jinjian Mu and Mat Makowski and Makhene, \{Mamodikoe K.\} and Sonja Crandon and Montefiori, \{David C.\} and Roberts, \{Paul C.\} and Beigel, \{John H.\}",

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AU - Baden, Lindsey R.

AU - Anderson, Evan J.

AU - Luetkemeyer, Anne F.

AU - Diemert, David J.

AU - Winokur, Patricia L.

AU - Presti, Rachel M.

AU - Kottkamp, Angelica C.

AU - Falsey, Ann R.

AU - Frey, Sharon E.

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AU - Bäcker, Martín

AU - Novak, Richard M.

AU - Walter, Emmanuel B.

AU - Jackson, Lisa A.

AU - Little, Susan J.

AU - Immergluck, Lilly C.

AU - Mahgoub, Siham M.

AU - Whitaker, Jennifer A.

AU - Babu, Tara M.

AU - Goepfert, Paul A.

AU - Fusco, Dahlene N.

AU - Atmar, Robert L.

AU - Posavad, Christine M.

AU - Netzl, Antonia

AU - Smith, Derek J.

AU - Telu, Kalyani

AU - Mu, Jinjian

AU - Makowski, Mat

AU - Makhene, Mamodikoe K.

AU - Crandon, Sonja

AU - Montefiori, David C.

AU - Roberts, Paul C.

AU - Beigel, John H.

PY - 2023/8/15

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KW - SARS-CoV-2

KW - vaccine

KW - variant

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Immunogenicity of the BA.1 and BA.4/BA.5 Severe Acute Respiratory Syndrome Coronavirus 2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial

Abstract

Keywords

ASJC Scopus subject areas

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