Immunoglobulin A and secretory immunoglobulin A antibodies to purified type 1 Klebsiella pneumoniae pili in human colostrum

C. P. Davis, C. W. Houston, R. C. Fader, R. M. Goldblum, E. A. Weaver, A. S. Goldman

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    Abstract

    Immunoglobulin A antibodies with binding specificity for purified Klebsiella pneumoniae type 1 pili were detected by an enzyme-linked immunosorbent assay in 20 of 21 human samples (95%). The concentrations of secretory immunoglobulin A antibody in colostrum directed against the pili were calculated by comparison of experimental enzyme-linked immunosorbent assay values with values obtained from known secretory immunoglobulin A concentrations. The presence of antibodies to K. pneumoniae type 1 pili was confirmed by double diffusion-gell studies with selected specimens of colostrum. This study shows that in the majority of human colostral samples examined, secretory immunoglobulin A antibodies with specificity for K. pneumoniae type 1 pili can be commonly found in variable, but frequently high, concentrations.

    Original languageEnglish (US)
    Pages (from-to)496-501
    Number of pages6
    JournalInfection and Immunity
    Volume38
    Issue number2
    StatePublished - 1982

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    ASJC Scopus subject areas

    • Immunology

    Cite this

    Davis, C. P., Houston, C. W., Fader, R. C., Goldblum, R. M., Weaver, E. A., & Goldman, A. S. (1982). Immunoglobulin A and secretory immunoglobulin A antibodies to purified type 1 Klebsiella pneumoniae pili in human colostrum. Infection and Immunity, 38(2), 496-501.