Immunoglobulin A and secretory immunoglobulin A antibodies to purified type 1 Klebsiella pneumoniae pili in human colostrum

C. P. Davis, C. W. Houston, R. C. Fader, R. M. Goldblum, E. A. Weaver, A. S. Goldman

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Immunoglobulin A antibodies with binding specificity for purified Klebsiella pneumoniae type 1 pili were detected by an enzyme-linked immunosorbent assay in 20 of 21 human samples (95%). The concentrations of secretory immunoglobulin A antibody in colostrum directed against the pili were calculated by comparison of experimental enzyme-linked immunosorbent assay values with values obtained from known secretory immunoglobulin A concentrations. The presence of antibodies to K. pneumoniae type 1 pili was confirmed by double diffusion-gell studies with selected specimens of colostrum. This study shows that in the majority of human colostral samples examined, secretory immunoglobulin A antibodies with specificity for K. pneumoniae type 1 pili can be commonly found in variable, but frequently high, concentrations.

    Original languageEnglish (US)
    Pages (from-to)496-501
    Number of pages6
    JournalInfection and Immunity
    Volume38
    Issue number2
    StatePublished - 1982

    Fingerprint

    Secretory Immunoglobulin A
    Colostrum
    Klebsiella pneumoniae
    Immunoglobulin A
    Antibodies
    Enzyme-Linked Immunosorbent Assay
    Antibody Specificity
    Gels

    ASJC Scopus subject areas

    • Immunology

    Cite this

    Davis, C. P., Houston, C. W., Fader, R. C., Goldblum, R. M., Weaver, E. A., & Goldman, A. S. (1982). Immunoglobulin A and secretory immunoglobulin A antibodies to purified type 1 Klebsiella pneumoniae pili in human colostrum. Infection and Immunity, 38(2), 496-501.

    Immunoglobulin A and secretory immunoglobulin A antibodies to purified type 1 Klebsiella pneumoniae pili in human colostrum. / Davis, C. P.; Houston, C. W.; Fader, R. C.; Goldblum, R. M.; Weaver, E. A.; Goldman, A. S.

    In: Infection and Immunity, Vol. 38, No. 2, 1982, p. 496-501.

    Research output: Contribution to journalArticle

    Davis, CP, Houston, CW, Fader, RC, Goldblum, RM, Weaver, EA & Goldman, AS 1982, 'Immunoglobulin A and secretory immunoglobulin A antibodies to purified type 1 Klebsiella pneumoniae pili in human colostrum', Infection and Immunity, vol. 38, no. 2, pp. 496-501.
    Davis, C. P. ; Houston, C. W. ; Fader, R. C. ; Goldblum, R. M. ; Weaver, E. A. ; Goldman, A. S. / Immunoglobulin A and secretory immunoglobulin A antibodies to purified type 1 Klebsiella pneumoniae pili in human colostrum. In: Infection and Immunity. 1982 ; Vol. 38, No. 2. pp. 496-501.
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    abstract = "Immunoglobulin A antibodies with binding specificity for purified Klebsiella pneumoniae type 1 pili were detected by an enzyme-linked immunosorbent assay in 20 of 21 human samples (95{\%}). The concentrations of secretory immunoglobulin A antibody in colostrum directed against the pili were calculated by comparison of experimental enzyme-linked immunosorbent assay values with values obtained from known secretory immunoglobulin A concentrations. The presence of antibodies to K. pneumoniae type 1 pili was confirmed by double diffusion-gell studies with selected specimens of colostrum. This study shows that in the majority of human colostral samples examined, secretory immunoglobulin A antibodies with specificity for K. pneumoniae type 1 pili can be commonly found in variable, but frequently high, concentrations.",
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