Immunohistochemical characterization of thyroid gland angiomatoid tumors

Robert T. Cutlan, Jack E. Greer, Frank S. Wong, Mahmoud Eltorky

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The histogenesis of thyroid gland angiomatoid tumors, probably as a primary angiosarcoma, has been a controversy for many years. These tumors may be variants of undifferentiated (anaplastic) carcinomas. We report a thyroid gland angiomatoid carcinoma in a 61-year-old African American male. The tumor had a heterogeneous pattern with both sarcomatous and epithelioid areas. Tumor cells lined some vascular-like spaces and others had intracytoplasmic lumens containing red blood cells. The tumor cells were found to express multiple endothelial (factor VIII-related antigen, CD31, CD34, and Ulex europaeus I lectin) and epithelial (cytokeratin and epithelial membrane antigen) markers as well as thyroglobulin by immunohistochemistry. This rare presentation demonstrates the heterogeneous nature of thyroid gland angiomatoid carcinoma with both epithelial and endothelial differentiation. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)159-164
Number of pages6
JournalExperimental and Molecular Pathology
Volume69
Issue number2
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Tumors
Thyroid Gland
Carcinoma
Cells
Neoplasms
Mucin-1
Hemangiosarcoma
Thyroglobulin
von Willebrand Factor
Keratins
African Americans
Blood Vessels
Blood
Erythrocytes
Immunohistochemistry

Keywords

  • Anaplastic carcinoma
  • Angiomatoid carcinoma
  • Angiosarcoma
  • Thyroid gland
  • Undifferentiated carcinoma

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

Cite this

Immunohistochemical characterization of thyroid gland angiomatoid tumors. / Cutlan, Robert T.; Greer, Jack E.; Wong, Frank S.; Eltorky, Mahmoud.

In: Experimental and Molecular Pathology, Vol. 69, No. 2, 2000, p. 159-164.

Research output: Contribution to journalArticle

Cutlan, Robert T. ; Greer, Jack E. ; Wong, Frank S. ; Eltorky, Mahmoud. / Immunohistochemical characterization of thyroid gland angiomatoid tumors. In: Experimental and Molecular Pathology. 2000 ; Vol. 69, No. 2. pp. 159-164.
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