Immunohistochemical evidence for sprouting of ventral root afferents after neonatal sciatic neurectomy in the rat

Mae Ja Park; Kyungsoon Chung; Jin Mo Chung

doi:10.1016/0304-3940(94)90725-0

Immunohistochemical evidence for sprouting of ventral root afferents after neonatal sciatic neurectomy in the rat

Mae Ja Park, Kyungsoon Chung, Jin Mo Chung

Neuroscience & Cell

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The present study demonstrates that afferent fibers in the rat ventral root sprout after transection of the neonatal sciatic nerve. The key data are that the number of unmyelinated fibers increased dramatically in the L₅ ventral roots and about half of these unmyelinated fibers were labeled with antibody to growth associated phosphoprotein (GAP-43), suggesting that they are regenerating axons. Furthermore, these fibers survived in the distal stump of the acutely cut ventral root, suggesting that they are afferent fibers. The results provide direct evidence for sprouting of afferent fibers in the ventral root induced by a neonatal peripheral nerve lesion.

Original language	English (US)
Pages (from-to)	125-128
Number of pages	4
Journal	Neuroscience Letters
Volume	165
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(94)90725-0
State	Published - Jan 3 1994

Keywords

Dorsal root ganglion
GAP-43
Regeneration
Unmyelinated fiber

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(94)90725-0

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title = "Immunohistochemical evidence for sprouting of ventral root afferents after neonatal sciatic neurectomy in the rat",

abstract = "The present study demonstrates that afferent fibers in the rat ventral root sprout after transection of the neonatal sciatic nerve. The key data are that the number of unmyelinated fibers increased dramatically in the L5 ventral roots and about half of these unmyelinated fibers were labeled with antibody to growth associated phosphoprotein (GAP-43), suggesting that they are regenerating axons. Furthermore, these fibers survived in the distal stump of the acutely cut ventral root, suggesting that they are afferent fibers. The results provide direct evidence for sprouting of afferent fibers in the ventral root induced by a neonatal peripheral nerve lesion.",

keywords = "Dorsal root ganglion, GAP-43, Regeneration, Unmyelinated fiber",

author = "Park, {Mae Ja} and Kyungsoon Chung and Chung, {Jin Mo}",

note = "Funding Information: This work was supported by NIH Grants NS 21266 and NS 11255, the John Sealy Memorial Endowment Fund and a grant from Bristol-Myers Squibb Co. We wish to thank M.L. Watson for editorial help.",

year = "1994",

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doi = "10.1016/0304-3940(94)90725-0",

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pages = "125--128",

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T1 - Immunohistochemical evidence for sprouting of ventral root afferents after neonatal sciatic neurectomy in the rat

AU - Park, Mae Ja

AU - Chung, Kyungsoon

AU - Chung, Jin Mo

N1 - Funding Information: This work was supported by NIH Grants NS 21266 and NS 11255, the John Sealy Memorial Endowment Fund and a grant from Bristol-Myers Squibb Co. We wish to thank M.L. Watson for editorial help.

PY - 1994/1/3

Y1 - 1994/1/3

N2 - The present study demonstrates that afferent fibers in the rat ventral root sprout after transection of the neonatal sciatic nerve. The key data are that the number of unmyelinated fibers increased dramatically in the L5 ventral roots and about half of these unmyelinated fibers were labeled with antibody to growth associated phosphoprotein (GAP-43), suggesting that they are regenerating axons. Furthermore, these fibers survived in the distal stump of the acutely cut ventral root, suggesting that they are afferent fibers. The results provide direct evidence for sprouting of afferent fibers in the ventral root induced by a neonatal peripheral nerve lesion.

AB - The present study demonstrates that afferent fibers in the rat ventral root sprout after transection of the neonatal sciatic nerve. The key data are that the number of unmyelinated fibers increased dramatically in the L5 ventral roots and about half of these unmyelinated fibers were labeled with antibody to growth associated phosphoprotein (GAP-43), suggesting that they are regenerating axons. Furthermore, these fibers survived in the distal stump of the acutely cut ventral root, suggesting that they are afferent fibers. The results provide direct evidence for sprouting of afferent fibers in the ventral root induced by a neonatal peripheral nerve lesion.

KW - Dorsal root ganglion

KW - GAP-43

KW - Regeneration

KW - Unmyelinated fiber

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Immunohistochemical evidence for sprouting of ventral root afferents after neonatal sciatic neurectomy in the rat

Abstract

Keywords

ASJC Scopus subject areas

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