Immunohistochemical evidence for sprouting of ventral root afferents after neonatal sciatic neurectomy in the rat

Mae Ja Park, Kyungsoon Chung, Jin Chung

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The present study demonstrates that afferent fibers in the rat ventral root sprout after transection of the neonatal sciatic nerve. The key data are that the number of unmyelinated fibers increased dramatically in the L5 ventral roots and about half of these unmyelinated fibers were labeled with antibody to growth associated phosphoprotein (GAP-43), suggesting that they are regenerating axons. Furthermore, these fibers survived in the distal stump of the acutely cut ventral root, suggesting that they are afferent fibers. The results provide direct evidence for sprouting of afferent fibers in the ventral root induced by a neonatal peripheral nerve lesion.

Original languageEnglish (US)
Pages (from-to)125-128
Number of pages4
JournalNeuroscience Letters
Volume165
Issue number1-2
DOIs
StatePublished - Jan 3 1994

Fingerprint

Spinal Nerve Roots
GAP-43 Protein
Phosphoproteins
Sciatic Nerve
Peripheral Nerves
Axons
Antibodies
Growth

Keywords

  • Dorsal root ganglion
  • GAP-43
  • Regeneration
  • Unmyelinated fiber

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Immunohistochemical evidence for sprouting of ventral root afferents after neonatal sciatic neurectomy in the rat. / Park, Mae Ja; Chung, Kyungsoon; Chung, Jin.

In: Neuroscience Letters, Vol. 165, No. 1-2, 03.01.1994, p. 125-128.

Research output: Contribution to journalArticle

@article{33388d3b5e2941dca9f5aefec3d9a03a,
title = "Immunohistochemical evidence for sprouting of ventral root afferents after neonatal sciatic neurectomy in the rat",
abstract = "The present study demonstrates that afferent fibers in the rat ventral root sprout after transection of the neonatal sciatic nerve. The key data are that the number of unmyelinated fibers increased dramatically in the L5 ventral roots and about half of these unmyelinated fibers were labeled with antibody to growth associated phosphoprotein (GAP-43), suggesting that they are regenerating axons. Furthermore, these fibers survived in the distal stump of the acutely cut ventral root, suggesting that they are afferent fibers. The results provide direct evidence for sprouting of afferent fibers in the ventral root induced by a neonatal peripheral nerve lesion.",
keywords = "Dorsal root ganglion, GAP-43, Regeneration, Unmyelinated fiber",
author = "Park, {Mae Ja} and Kyungsoon Chung and Jin Chung",
year = "1994",
month = "1",
day = "3",
doi = "10.1016/0304-3940(94)90725-0",
language = "English (US)",
volume = "165",
pages = "125--128",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Immunohistochemical evidence for sprouting of ventral root afferents after neonatal sciatic neurectomy in the rat

AU - Park, Mae Ja

AU - Chung, Kyungsoon

AU - Chung, Jin

PY - 1994/1/3

Y1 - 1994/1/3

N2 - The present study demonstrates that afferent fibers in the rat ventral root sprout after transection of the neonatal sciatic nerve. The key data are that the number of unmyelinated fibers increased dramatically in the L5 ventral roots and about half of these unmyelinated fibers were labeled with antibody to growth associated phosphoprotein (GAP-43), suggesting that they are regenerating axons. Furthermore, these fibers survived in the distal stump of the acutely cut ventral root, suggesting that they are afferent fibers. The results provide direct evidence for sprouting of afferent fibers in the ventral root induced by a neonatal peripheral nerve lesion.

AB - The present study demonstrates that afferent fibers in the rat ventral root sprout after transection of the neonatal sciatic nerve. The key data are that the number of unmyelinated fibers increased dramatically in the L5 ventral roots and about half of these unmyelinated fibers were labeled with antibody to growth associated phosphoprotein (GAP-43), suggesting that they are regenerating axons. Furthermore, these fibers survived in the distal stump of the acutely cut ventral root, suggesting that they are afferent fibers. The results provide direct evidence for sprouting of afferent fibers in the ventral root induced by a neonatal peripheral nerve lesion.

KW - Dorsal root ganglion

KW - GAP-43

KW - Regeneration

KW - Unmyelinated fiber

UR - http://www.scopus.com/inward/record.url?scp=0028139982&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028139982&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(94)90725-0

DO - 10.1016/0304-3940(94)90725-0

M3 - Article

VL - 165

SP - 125

EP - 128

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -