Immunohistochemistry

Nahal Boroumand

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Immunohistochemistry is important for both distinguishing benign mesothelial proliferations from diffuse malignant mesothelioma (DMM) and for differentiating DMM from metastatic malignancies involving the pleura. Histologic diagnosis alone is often impossible. The exact makeup of immunohistochemical panels used for DMM diagnosis depends on the differential diagnosis and on the antibodies available in a given laboratory. Distinguishing reactive mesothelial cell hyperplasia from DMM is a significant challenge for which the role of immunohistochemistry is limited; however, it is extremely helpful when examining tissue for invasion to the stroma, fat, or lung parenchyma. The role of immunohistochemistry is also relatively limited in sarcomatous DMM diagnosis because mesothelial markers are less often positive.

Original languageEnglish (US)
Title of host publicationDiffuse Malignant Mesothelioma
PublisherSpringer New York
Pages93-105
Number of pages13
ISBN (Print)9781493923748, 9781493923731
DOIs
StatePublished - Jan 1 2015

Keywords

  • Calretinin
  • Immunohistochemistry
  • Keratin
  • Mesothelioma
  • Thrombomodulin
  • WT1

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Boroumand, N. (2015). Immunohistochemistry. In Diffuse Malignant Mesothelioma (pp. 93-105). Springer New York. https://doi.org/10.1007/978-1-4939-2374-8_5