Immunologic effects of nonsteroidal anti-inflammatory drugs

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Abstract

Recent studies of the immunoregulatory effects of prostaglandin and the immunomodulating actions of nonsteroidal anti-inflammatory drugs reveal that earlier reports of inhibition of prostaglandin synthesis by nonsteroidal anti-inflammatory drugs cannot alone fully explain the anti-inflammatory properties of these agents. Data defining the complex inter-relationship of prostaglandin, the immune response, and nonsteroidal anti-inflammatory drugs are reviewed, and possible mechanisms of anti-inflammatory action of these agents are considered. The effects of nonsteroidal anti-inflammatory drugs on cellular immune function and humoral immune response suggest that anti-inflammatory activity may be related to altered suppressor cell function, inhibition of monocyte collagenase release, or inhibition of neutrophil migration and activation. Further elucidation is awaited.

Original languageEnglish (US)
Pages (from-to)7-15
Number of pages9
JournalAmerican Journal of Medicine
Volume77
Issue number4 B
StatePublished - Jan 1 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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