Abstract
Recent studies of the immunoregulatory effects of prostaglandin and the immunomodulating actions of nonsteroidal anti-inflammatory drugs reveal that earlier reports of inhibition of prostaglandin synthesis by nonsteroidal anti-inflammatory drugs cannot alone fully explain the anti-inflammatory properties of these agents. Data defining the complex inter-relationship of prostaglandin, the immune response, and nonsteroidal anti-inflammatory drugs are reviewed, and possible mechanisms of anti-inflammatory action of these agents are considered. The effects of nonsteroidal anti-inflammatory drugs on cellular immune function and humoral immune response suggest that anti-inflammatory activity may be related to altered suppressor cell function, inhibition of monocyte collagenase release, or inhibition of neutrophil migration and activation. Further elucidation is awaited.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7-15 |
| Number of pages | 9 |
| Journal | American Journal of Medicine |
| Volume | 77 |
| Issue number | 4 B |
| State | Published - Jan 1 1984 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)