Immunologic studies in asymptomatic hemophilia patients. Relationship to acquired immune deficiency syndrome (AIDS)

A. Landay, M. C. Poon, T. Abo, S. Stagno, A. Lurie, M. D. Cooper

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Asymptomatic hemophilia patients receiving Factor VIII concentrate were found to have normal natural killer (NK) cells and B cells, and an inverted T helper-suppressor ratio due to an increase in cells of T suppressor phenotype. In contrast, a hemophilia patient with acquired immune deficiency syndrome (AIDS) exhibited nonfunctional NK cells, low B cells, and an inverted T helper/suppressor ratio due to very low numbers of T helper cells. Hemophilia patients on cryoprecipitate therapy exhibited normal immune parameters. A high percentage of hemophilia patients on both treatments had antibody to hepatitis B virus. The isolated finding of elevated levels of T suppressor cells in hemophilia patients receiving Factor VIII concentrate has not been recognized as an early indicator of impending AIDS, and longitudinal studies will be required to determine its clinical significance.

Original languageEnglish (US)
Pages (from-to)1500-1504
Number of pages5
JournalUnknown Journal
Volume71
Issue number5
DOIs
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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