Immunological treatment options for locoregionally advanced head and neck squamous cell carcinoma

Christopher Schutt; Klaus Bumm; Leonardo Mirandola; Giovanni Bernardini; Nicholas D. Cunha; Lukman Tijani; Diane Nguyen; Joehassin Cordero; Marjorie R. Jenkins; Everardo Cobos; W. Martin Kast; Maurizio Chiriva-Internati

doi:10.3109/08830185.2011.637253

Immunological treatment options for locoregionally advanced head and neck squamous cell carcinoma

Christopher Schutt, Klaus Bumm, Leonardo Mirandola, Giovanni Bernardini, Nicholas D. Cunha, Lukman Tijani, Diane Nguyen, Joehassin Cordero, Marjorie R. Jenkins, Everardo Cobos, W. Martin Kast, Maurizio Chiriva-Internati

Internal Medicine

Research output: Contribution to journal › Article

9 Scopus citations

Abstract

Patients with squamous cell carcinoma of the head and neck (HNSCC) are usually treated by a multimodal approach with surgery and/or radiochemotherapy as the mainstay of localregional treatment in cases with advanced disease. Both chemotherapy and radiation therapy have the disadvantage of causing severe side effects, while the clinical outcome of patients diagnosed with HNSCC has remained essentially unchanged over the last decade. The potential of immunotherapy is still largely unexplored. Here the authors review the current status of the art and discuss the future challenges in HNSCC treatment and prevention.

Original language	English (US)
Pages (from-to)	22-42
Number of pages	21
Journal	International Reviews of Immunology
Volume	31
Issue number	1
DOIs	https://doi.org/10.3109/08830185.2011.637253
State	Published - Feb 2012

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Keywords

Cancer vaccines
CRT
EGFR
HNSCC
HPV

ASJC Scopus subject areas

Immunology
Immunology and Allergy

Cite this

Schutt, C., Bumm, K., Mirandola, L., Bernardini, G., Cunha, N. D., Tijani, L., Nguyen, D., Cordero, J., Jenkins, M. R., Cobos, E., Kast, W. M., & Chiriva-Internati, M. (2012). Immunological treatment options for locoregionally advanced head and neck squamous cell carcinoma. International Reviews of Immunology, 31(1), 22-42. https://doi.org/10.3109/08830185.2011.637253

Immunological treatment options for locoregionally advanced head and neck squamous cell carcinoma. / Schutt, Christopher; Bumm, Klaus; Mirandola, Leonardo; Bernardini, Giovanni; Cunha, Nicholas D.; Tijani, Lukman; Nguyen, Diane; Cordero, Joehassin; Jenkins, Marjorie R.; Cobos, Everardo; Kast, W. Martin; Chiriva-Internati, Maurizio.

In: International Reviews of Immunology, Vol. 31, No. 1, 02.2012, p. 22-42.

Research output: Contribution to journal › Article

Schutt, Christopher ; Bumm, Klaus ; Mirandola, Leonardo ; Bernardini, Giovanni ; Cunha, Nicholas D. ; Tijani, Lukman ; Nguyen, Diane ; Cordero, Joehassin ; Jenkins, Marjorie R. ; Cobos, Everardo ; Kast, W. Martin ; Chiriva-Internati, Maurizio. / Immunological treatment options for locoregionally advanced head and neck squamous cell carcinoma. In: International Reviews of Immunology. 2012 ; Vol. 31, No. 1. pp. 22-42.

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10.3109/08830185.2011.637253