Immunometabolism in tuberculosis

Lanbo Shi, Eliseo Eugenin, Selvakumar Subbian

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Immunometabolism, the study of the relationship between bioenergetic pathways and specific functions of immune cells, has recently gained increasing appreciation. In response to infection, activation of the host innate and adaptive immune cells is accompanied by a switch in the bioenergetic pathway from oxidative phosphorylation to glycolysis, a metabolic remodeling known as the Warburg effect, which is required for the production of antimicrobial and pro-inflammatory effector molecules. In this review, we summarize the current understanding of the Warburg effect and discuss its association with the expression of host immune responses in tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb). We also discuss potential mechanisms underlying the Warburg effect with a focus on the expression and regulation of hypoxia-inducible factor 1 alpha (HIF-1α), the regulatory subunit of HIF-1, a major transcription regulator involved in cellular stress adaptation processes, including energy metabolism and antimicrobial responses. We also propose a novel hypothesis that Mtb perturbs the Warburg effect of immune cells to facilitate its survival and persistence in the host. A better understanding of the dynamics of metabolic states of immune cells and their specific functions during TB pathogenesis can lead to the development of immunotherapies capable of promoting Mtb clearance and reducing Mtb persistence and the emergence of drug resistant strains.

Original languageEnglish (US)
Article number150
JournalFrontiers in Immunology
Volume7
Issue numberAPR
DOIs
StatePublished - Apr 21 2016
Externally publishedYes

Fingerprint

Mycobacterium tuberculosis
Tuberculosis
Energy Metabolism
Alpha Subunit Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1
Oxidative Phosphorylation
Glycolysis
Immunotherapy
Communicable Diseases
Infection
Pharmaceutical Preparations

Keywords

  • Granuloma
  • Hypoxia-inducible factor 1 alpha
  • Immune response
  • Metabolism
  • The Warburg effect
  • Tuberculosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Immunometabolism in tuberculosis. / Shi, Lanbo; Eugenin, Eliseo; Subbian, Selvakumar.

In: Frontiers in Immunology, Vol. 7, No. APR, 150, 21.04.2016.

Research output: Contribution to journalReview article

Shi, Lanbo ; Eugenin, Eliseo ; Subbian, Selvakumar. / Immunometabolism in tuberculosis. In: Frontiers in Immunology. 2016 ; Vol. 7, No. APR.
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