Immunomodulatory and neuroprotective effects of inosine

György Haskó, Michail V. Sitkovsky, Csaba Szabó

    Research output: Contribution to journalReview article

    175 Scopus citations

    Abstract

    Adenosine has been considered as a potential immunomodulatory and neuroprotective agent for 30 years. Inosine, a major degradation product of adenosine, was thought originally to have no biological effects. However, recent studies demonstrate that inosine has potent immunomodulatory and neuroprotective effects. Inosine enhances mast-cell degranulation, attenuates the production of pro-inflammatory mediators by macrophages, lymphocytes and neutrophils, and is protective in animal models of sepsis, ischemia-reperfusion and autoimmunity. Inosine preserves the viability of glial cells and neuronal cells during hypoxia, and stimulates axonal regrowth after injury. The biological actions of inosine might involve effects on adenosine receptors, poly(ADP-ribose) polymerase and cellular energy levels. In this article, we review recent observations indicating that it might be possible to exploit inosine therapeutically for the treatment of tissue damage caused by inflammation and ischemia.

    Original languageEnglish (US)
    Pages (from-to)152-157
    Number of pages6
    JournalTrends in Pharmacological Sciences
    Volume25
    Issue number3
    DOIs
    StatePublished - Mar 2004

      Fingerprint

    ASJC Scopus subject areas

    • Toxicology
    • Pharmacology

    Cite this