Immunomodulatory and neuroprotective effects of inosine

György Haskó, Michail V. Sitkovsky, Csaba Szabo

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

Adenosine has been considered as a potential immunomodulatory and neuroprotective agent for 30 years. Inosine, a major degradation product of adenosine, was thought originally to have no biological effects. However, recent studies demonstrate that inosine has potent immunomodulatory and neuroprotective effects. Inosine enhances mast-cell degranulation, attenuates the production of pro-inflammatory mediators by macrophages, lymphocytes and neutrophils, and is protective in animal models of sepsis, ischemia-reperfusion and autoimmunity. Inosine preserves the viability of glial cells and neuronal cells during hypoxia, and stimulates axonal regrowth after injury. The biological actions of inosine might involve effects on adenosine receptors, poly(ADP-ribose) polymerase and cellular energy levels. In this article, we review recent observations indicating that it might be possible to exploit inosine therapeutically for the treatment of tissue damage caused by inflammation and ischemia.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
JournalTrends in Pharmacological Sciences
Volume25
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Inosine
Neuroprotective Agents
Adenosine
Ischemia
Cell Degranulation
Cell Hypoxia
Purinergic P1 Receptors
Lymphocytes
Poly(ADP-ribose) Polymerases
Lymphokines
Macrophages
Autoimmunity
Mast Cells
Neuroglia
Electron energy levels
Reperfusion
Sepsis
Animals
Neutrophils
Animal Models

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Immunomodulatory and neuroprotective effects of inosine. / Haskó, György; Sitkovsky, Michail V.; Szabo, Csaba.

In: Trends in Pharmacological Sciences, Vol. 25, No. 3, 03.2004, p. 152-157.

Research output: Contribution to journalArticle

Haskó, György ; Sitkovsky, Michail V. ; Szabo, Csaba. / Immunomodulatory and neuroprotective effects of inosine. In: Trends in Pharmacological Sciences. 2004 ; Vol. 25, No. 3. pp. 152-157.
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