Immunomodulatory effects of lactobacillus biogenic administration in dogs

Junro Hayasaka, Yuka Nunomura, Miki Omura, Yukie Katayama, Tomoko Yokota, Nanako Osawa, Shinji Makino, Tetsuya Mizutani, Tsuyoshi Uchide, Yoshiteru Murata

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Lactobacillus biogenics were administered to four dogs for 56 days. The regulatory T cell (Treg) count was found to be increased in all four dogs on 56 days. On day 112, 56 days after completion of Lactobacillus probiotic administration, the percentage of Tregs was found to be decreased in three dogs. Plasma IgA levels tended to increase after stopping Lactobacillus administration. Metagenomic analysis of bacterial flora found in dog feces revealed that Firmicutes, Proteobacteria, Bacteroidetes, and Fusobacteria were predominantly found in all 4 dogs. Analysis of fecal microbiomes of species level on day 56 showed that 99 % members of genus Prevotella belonged to species copri. This study demonstrates some of the immunomodulatory effects of Lactobacillus probiotics on dogs.

Original languageEnglish (US)
Pages (from-to)175-182
Number of pages8
JournalJapanese Journal of Veterinary Research
Issue number3
StatePublished - Aug 2021


  • Lactobacillus probiotics
  • Regulatory T cells

ASJC Scopus subject areas

  • General Veterinary


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