Immunopathogenesis of respiratory syncytial virus bronchiolitis

Berkeley L. Bennett, Roberto Garofalo, Stanley G. Cron, Yashoda Hosakote Madaiah, Robert L. Atmar, Charles G. Macias, Pedro A. Piedra

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Background. The objective of this study was to elucidate the relation between respiratory syncytial virus (RSV) infection and cytokine/chemokine concentrations, as well as the impact that these factors have on the severity of bronchiolitis. Methods. Children <24 months old who presented to the emergency department with clinical symptoms of bronchiolitis were prospectively enrolled in the study. Nasal-wash samples were analyzed to identify viral pathogens and to quantify RSV and cytokine/chemokine concentrations. Severe cases of disease were defined as those requiring hospitalization, and severity was further determined on the basis of the duration of supplemental-oxygen and/or intravenous-fluid therapy. Results. A total of 101 children were enrolled, 63 of whom were infected with RSV and 13 of whom were infected with other respiratory viruses; in 22 children, no virus was detected. RSV bronchiolitis was associated with a greater inflammatory response than was non-RSV bronchiolitis, although RSV infection was not associated with more-severe disease. Levels of interleukin (IL)-6, IL-8, IL-10, interferon (IFN)-γ, and macrophage inflammatory protein (MIP)-1β were significantly inversely correlated with the duration of supplemental-oxygen therapy. Conclusion. The robust inflammatory response associated with RSV infection does not contribute to the severity of RSV bronchiolitis any more than it contributes to the severity of non-RSV bronchiolitis. Elevated levels of proinflammatory mediators IL-6, IL-8, IFN-γ, and MIP-1β, as well as of the regulatory cytokine IL-10, may be protective against hypoxia in bronchiolitis.

Original languageEnglish (US)
Pages (from-to)1532-1540
Number of pages9
JournalJournal of Infectious Diseases
Volume195
Issue number10
DOIs
StatePublished - May 15 2007

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Bronchiolitis
Respiratory Syncytial Viruses
Respiratory Syncytial Virus Infections
Viruses
Macrophage Inflammatory Proteins
Cytokines
Interleukin-8
Chemokines
Interleukin-10
Interferons
Interleukin-6
Oxygen
Fluid Therapy
Nose
Hospital Emergency Service
Hospitalization

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Bennett, B. L., Garofalo, R., Cron, S. G., Hosakote Madaiah, Y., Atmar, R. L., Macias, C. G., & Piedra, P. A. (2007). Immunopathogenesis of respiratory syncytial virus bronchiolitis. Journal of Infectious Diseases, 195(10), 1532-1540. https://doi.org/10.1086/515575

Immunopathogenesis of respiratory syncytial virus bronchiolitis. / Bennett, Berkeley L.; Garofalo, Roberto; Cron, Stanley G.; Hosakote Madaiah, Yashoda; Atmar, Robert L.; Macias, Charles G.; Piedra, Pedro A.

In: Journal of Infectious Diseases, Vol. 195, No. 10, 15.05.2007, p. 1532-1540.

Research output: Contribution to journalArticle

Bennett, Berkeley L. ; Garofalo, Roberto ; Cron, Stanley G. ; Hosakote Madaiah, Yashoda ; Atmar, Robert L. ; Macias, Charles G. ; Piedra, Pedro A. / Immunopathogenesis of respiratory syncytial virus bronchiolitis. In: Journal of Infectious Diseases. 2007 ; Vol. 195, No. 10. pp. 1532-1540.
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