Immunoreactive atrial natriuretic factor is increased in ovine model of endotoxemia

H. J. Lubbesmeyer, L. Woodson, L. D. Traber, J. T. Flynn, David Herndon, D. L. Traber

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A bolus of Escherichia coli endotoxin (1.5 μg/kg) was administered to chronically instrumented sheep. Immunoreactive atrial natriuretic factor (IR-ANF) was measured in extracted plasma by radioimmunoassay. There was a thirteenfold increase in IR-ANF 2 h after endotoxin administration, and IR-ANF levels remained significantly elevated during the first 6 h. A marked diuresis and natriuresis occurred between 4 and 6 h. ANF not only affects renal function but is also associated with decreased carciac output, increased peripheral resistance (in sheep), and decreased capillary absorption (in rats). These renal and hemodynamic changes are also characteristic of the early (first 6 h) response to endotoxin. Therefore ANF should be considered as a potential mediator of renal and hemodynamic changes induced by sepsis. It is difficult to determine if ANF elevation is an epiphenomenon or a causative factor, because no antagonist of ANF is currently available.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume254
Issue number4
StatePublished - 1988

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Endotoxemia
Atrial Natriuretic Factor
Sheep
Kidney
Endotoxins
Hemodynamics
Natriuresis
Diuresis
Vascular Resistance
Radioimmunoassay
Sepsis

ASJC Scopus subject areas

  • Physiology

Cite this

Lubbesmeyer, H. J., Woodson, L., Traber, L. D., Flynn, J. T., Herndon, D., & Traber, D. L. (1988). Immunoreactive atrial natriuretic factor is increased in ovine model of endotoxemia. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 254(4).

Immunoreactive atrial natriuretic factor is increased in ovine model of endotoxemia. / Lubbesmeyer, H. J.; Woodson, L.; Traber, L. D.; Flynn, J. T.; Herndon, David; Traber, D. L.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 254, No. 4, 1988.

Research output: Contribution to journalArticle

Lubbesmeyer, H. J. ; Woodson, L. ; Traber, L. D. ; Flynn, J. T. ; Herndon, David ; Traber, D. L. / Immunoreactive atrial natriuretic factor is increased in ovine model of endotoxemia. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1988 ; Vol. 254, No. 4.
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