Immunosuppressant Medications in Pregnancy

Antonio F. Saad, Luis D. Pacheco, George Saade

Research output: Contribution to journalReview articlepeer-review

Abstract

Pregnant patients are often on immunosuppressant medications, most commonly to manage transplantation or autoimmune disorders. Most immunosuppressant agents, including tacrolimus, corticosteroids, azathioprine, and calcineurin inhibitors, are safe during pregnancy and lactation. However, mycophenolic acid is associated with higher risks of birth defects and should be avoided in pregnancy. Tacrolimus, the commonly used drug in transplantation medicine and autoimmune disorders, requires monitoring of serum levels for dose adjustment, particularly during pregnancy. Although no pregnancy-specific therapeutic range exists, the general target range is 5-15 ng/mL, and pregnant patients may require higher doses to achieve therapeutic levels. Adherence to prescribed immunosuppressive regimens is crucial to prevent graft rejection and autoimmune disorder flare-ups. This review aims to provide essential information about the use of immunosuppressant medications in pregnant individuals. With a rising number of pregnant patients undergoing organ transplantations or having autoimmune disorders, it is important to understand the implications of the use of these medications during pregnancy.

Original languageEnglish (US)
Pages (from-to)E94-E106
JournalObstetrics and gynecology
Volume143
Issue number4
DOIs
StatePublished - Apr 1 2024
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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