Impact of Acinetobacter Infection on the Mortality of Burn Patients

Michael A. Albrecht, Matthew E. Griffith, Clinton K. Murray, Kevin K. Chung, Edward E. Horvath, John A. Ward, Duane R. Hospenthal, John B. Holcomb, Steven Wolf

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Background: Acinetobacter calcoaceticus-baumannii complex (Acb) is recognized as an important cause of nosocomial infections. Although Acb can be associated with multidrug resistance, its impact on mortality in burn patients has not been fully elucidated. Study design: In a retrospective cohort study assessing medical records and microbiology laboratory data at a US military tertiary care burn center, we evaluated all patients admitted to the burn center between January 2003 and November 2005. Data collected included age, severity of burn, comorbidities, length of stay, and survival to hospital discharge. In addition, microbiology data were reviewed to determine which patients were infected with Acb during this time frame. These data were then used to compare patients infected with Acb to patients not infected. Multivariate analysis using logistic regression was performed to determine which patient characteristics were associated with increased mortality. Results: There were 802 patients included in the study. Fifty-nine patients met the case definition for infection. An additional 52 patients were found to be colonized with Acb. Patients with Acb infection had more severe burns and comorbidities, and had longer lengths of stay compared with patients without Acb or those with Acb colonization. Mortality in infected patients was higher compared with those without infection (relative risk = 2.86, p = 0.001). On multivariate analysis, infection with Acb was not statistically associated with mortality. Conclusions: Multidrug-resistant Acb is a common cause of nosocomial infection in the burn patient population. Despite this, it does not independently affect mortality.

Original languageEnglish (US)
Pages (from-to)546-550
Number of pages5
JournalJournal of the American College of Surgeons
Volume203
Issue number4
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

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Acinetobacter Infections
Acinetobacter calcoaceticus
Acinetobacter baumannii
Mortality
Burn Units
Cross Infection
Microbiology
Infection
Comorbidity
Length of Stay
Multivariate Analysis
Multiple Drug Resistance

ASJC Scopus subject areas

  • Surgery

Cite this

Albrecht, M. A., Griffith, M. E., Murray, C. K., Chung, K. K., Horvath, E. E., Ward, J. A., ... Wolf, S. (2006). Impact of Acinetobacter Infection on the Mortality of Burn Patients. Journal of the American College of Surgeons, 203(4), 546-550. https://doi.org/10.1016/j.jamcollsurg.2006.06.013

Impact of Acinetobacter Infection on the Mortality of Burn Patients. / Albrecht, Michael A.; Griffith, Matthew E.; Murray, Clinton K.; Chung, Kevin K.; Horvath, Edward E.; Ward, John A.; Hospenthal, Duane R.; Holcomb, John B.; Wolf, Steven.

In: Journal of the American College of Surgeons, Vol. 203, No. 4, 01.10.2006, p. 546-550.

Research output: Contribution to journalArticle

Albrecht, MA, Griffith, ME, Murray, CK, Chung, KK, Horvath, EE, Ward, JA, Hospenthal, DR, Holcomb, JB & Wolf, S 2006, 'Impact of Acinetobacter Infection on the Mortality of Burn Patients', Journal of the American College of Surgeons, vol. 203, no. 4, pp. 546-550. https://doi.org/10.1016/j.jamcollsurg.2006.06.013
Albrecht, Michael A. ; Griffith, Matthew E. ; Murray, Clinton K. ; Chung, Kevin K. ; Horvath, Edward E. ; Ward, John A. ; Hospenthal, Duane R. ; Holcomb, John B. ; Wolf, Steven. / Impact of Acinetobacter Infection on the Mortality of Burn Patients. In: Journal of the American College of Surgeons. 2006 ; Vol. 203, No. 4. pp. 546-550.
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