Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

Alba Grifoni; Tonino Alonzi; Galit Alter; Douglas Mc Clain Noonan; Alan L. Landay; Adriana Albini; Delia Goletti

doi:10.3389/fimmu.2023.1146704

Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

Alba Grifoni, Tonino Alonzi, Galit Alter, Douglas Mc Clain Noonan, Alan L. Landay, Adriana Albini, Delia Goletti

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Knowledge of aging biology needs to be expanded due to the continuously growing number of elderly people worldwide. Aging induces changes that affect all systems of the body. The risk of cardiovascular disease and cancer increases with age. In particular, the age-induced adaptation of the immune system causes a greater susceptibility to infections and contributes to the inability to control pathogen growth and immune-mediated tissue damage. Since the impact of aging on immune function, is still to be fully elucidated, this review addresses some of the recent understanding of age-related changes affecting key components of immunity. The emphasis is on immunosenescence and inflammaging that are impacted by common infectious diseases that are characterized by a high mortality, and includes COVID-19, HIV and tuberculosis.

Original language	English (US)
Article number	1146704
Journal	Frontiers in immunology
Volume	14
DOIs	https://doi.org/10.3389/fimmu.2023.1146704
State	Published - 2023
Externally published	Yes

Keywords

aging
B cells
COVID-19
HIV
immunosenescence
innate cells
T cells
tuberculosis

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3389/fimmu.2023.1146704

Cite this

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title = "Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis",

abstract = "Knowledge of aging biology needs to be expanded due to the continuously growing number of elderly people worldwide. Aging induces changes that affect all systems of the body. The risk of cardiovascular disease and cancer increases with age. In particular, the age-induced adaptation of the immune system causes a greater susceptibility to infections and contributes to the inability to control pathogen growth and immune-mediated tissue damage. Since the impact of aging on immune function, is still to be fully elucidated, this review addresses some of the recent understanding of age-related changes affecting key components of immunity. The emphasis is on immunosenescence and inflammaging that are impacted by common infectious diseases that are characterized by a high mortality, and includes COVID-19, HIV and tuberculosis.",

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AU - Grifoni, Alba

AU - Alonzi, Tonino

AU - Alter, Galit

AU - Noonan, Douglas Mc Clain

AU - Landay, Alan L.

AU - Albini, Adriana

AU - Goletti, Delia

PY - 2023

Y1 - 2023

N2 - Knowledge of aging biology needs to be expanded due to the continuously growing number of elderly people worldwide. Aging induces changes that affect all systems of the body. The risk of cardiovascular disease and cancer increases with age. In particular, the age-induced adaptation of the immune system causes a greater susceptibility to infections and contributes to the inability to control pathogen growth and immune-mediated tissue damage. Since the impact of aging on immune function, is still to be fully elucidated, this review addresses some of the recent understanding of age-related changes affecting key components of immunity. The emphasis is on immunosenescence and inflammaging that are impacted by common infectious diseases that are characterized by a high mortality, and includes COVID-19, HIV and tuberculosis.

AB - Knowledge of aging biology needs to be expanded due to the continuously growing number of elderly people worldwide. Aging induces changes that affect all systems of the body. The risk of cardiovascular disease and cancer increases with age. In particular, the age-induced adaptation of the immune system causes a greater susceptibility to infections and contributes to the inability to control pathogen growth and immune-mediated tissue damage. Since the impact of aging on immune function, is still to be fully elucidated, this review addresses some of the recent understanding of age-related changes affecting key components of immunity. The emphasis is on immunosenescence and inflammaging that are impacted by common infectious diseases that are characterized by a high mortality, and includes COVID-19, HIV and tuberculosis.

KW - aging

KW - B cells

KW - COVID-19

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KW - tuberculosis

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Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

Abstract

Keywords

ASJC Scopus subject areas

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