Impact of bipolar disorder on a U.S. community sample

Joseph R. Calabrese, Robert M A Hirschfeld, Michael Reed, Marilyn A. Davies, Mark A. Frye, Paul E. Keck, Lydia Lewis, Susan L. McElroy, James P. McNulty, Karen Wagner

Research output: Contribution to journalArticle

249 Citations (Scopus)

Abstract

Background: Bipolar disorder is a chronic psychiatric illness characterized by depression and at least 1 manic or hypomanic episode during the lifetime of the illness. Bipolar symptoms have been associated with significant functional impairment. We conducted a study to determine the psychosocial impact of bipolar disorder in a U.S. community sample. Method: 3059 subjects were selected from a large epidemiologic study of bipolar prevalence that used the Mood Disorder Questionnaire (MDQ) to screen for bipolar I and II disorder. Subjects were surveyed from April 24, 2001, to August 6, 2001, using the Sheehan Disability Scale and the Social Adjustment Scale-Self Report. Comorbid disease data were also collected. Results: Of the 3059 subjects surveyed, 2450 (80%) returned completed surveys: 1167 (48%) subjects screened positive for bipolar disorder based on MDQ scores; 1283 (52%) screened negative. MDQ-positive subjects reported significantly (p < .0001) more difficulties with workrelated performance, social/leisure activities, and social/family interactions compared with MDQ-negative subjects. Younger subjects, aged 18 to 34 years, reported significantly (p = .003) more symptom days than did older MDQ-positive subjects. MDQ-positive women reported more disruption in social and family life, while MDQ-positive men reported being jailed, arrested, and convicted for crimes. Anxiety (30% vs. 6%), panic attacks (18% vs. 4%), migraine (24% vs. 11%), asthma (17% vs. 10%), and allergies (42% vs. 29%) were significantly (p < .05) more common in MDQ-positive versus MDQ-negative subjects. Conclusion: Bipolar disorder, as identified in a community sample using the Mood Disorder Questionnaire, was significantly associated with negative impact on the performance of workrelated, leisure, and interpersonal activities.

Original languageEnglish (US)
Pages (from-to)425-432
Number of pages8
JournalJournal of Clinical Psychiatry
Volume64
Issue number4
StatePublished - Apr 1 2003

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Bipolar Disorder
Mood Disorders
Leisure Activities
Surveys and Questionnaires
Social Adjustment
Panic Disorder
Crime
Interpersonal Relations
Migraine Disorders
Self Report
Psychiatry
Epidemiologic Studies
Hypersensitivity
Chronic Disease
Asthma
Anxiety
Depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Calabrese, J. R., Hirschfeld, R. M. A., Reed, M., Davies, M. A., Frye, M. A., Keck, P. E., ... Wagner, K. (2003). Impact of bipolar disorder on a U.S. community sample. Journal of Clinical Psychiatry, 64(4), 425-432.

Impact of bipolar disorder on a U.S. community sample. / Calabrese, Joseph R.; Hirschfeld, Robert M A; Reed, Michael; Davies, Marilyn A.; Frye, Mark A.; Keck, Paul E.; Lewis, Lydia; McElroy, Susan L.; McNulty, James P.; Wagner, Karen.

In: Journal of Clinical Psychiatry, Vol. 64, No. 4, 01.04.2003, p. 425-432.

Research output: Contribution to journalArticle

Calabrese, JR, Hirschfeld, RMA, Reed, M, Davies, MA, Frye, MA, Keck, PE, Lewis, L, McElroy, SL, McNulty, JP & Wagner, K 2003, 'Impact of bipolar disorder on a U.S. community sample', Journal of Clinical Psychiatry, vol. 64, no. 4, pp. 425-432.
Calabrese JR, Hirschfeld RMA, Reed M, Davies MA, Frye MA, Keck PE et al. Impact of bipolar disorder on a U.S. community sample. Journal of Clinical Psychiatry. 2003 Apr 1;64(4):425-432.
Calabrese, Joseph R. ; Hirschfeld, Robert M A ; Reed, Michael ; Davies, Marilyn A. ; Frye, Mark A. ; Keck, Paul E. ; Lewis, Lydia ; McElroy, Susan L. ; McNulty, James P. ; Wagner, Karen. / Impact of bipolar disorder on a U.S. community sample. In: Journal of Clinical Psychiatry. 2003 ; Vol. 64, No. 4. pp. 425-432.
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abstract = "Background: Bipolar disorder is a chronic psychiatric illness characterized by depression and at least 1 manic or hypomanic episode during the lifetime of the illness. Bipolar symptoms have been associated with significant functional impairment. We conducted a study to determine the psychosocial impact of bipolar disorder in a U.S. community sample. Method: 3059 subjects were selected from a large epidemiologic study of bipolar prevalence that used the Mood Disorder Questionnaire (MDQ) to screen for bipolar I and II disorder. Subjects were surveyed from April 24, 2001, to August 6, 2001, using the Sheehan Disability Scale and the Social Adjustment Scale-Self Report. Comorbid disease data were also collected. Results: Of the 3059 subjects surveyed, 2450 (80{\%}) returned completed surveys: 1167 (48{\%}) subjects screened positive for bipolar disorder based on MDQ scores; 1283 (52{\%}) screened negative. MDQ-positive subjects reported significantly (p < .0001) more difficulties with workrelated performance, social/leisure activities, and social/family interactions compared with MDQ-negative subjects. Younger subjects, aged 18 to 34 years, reported significantly (p = .003) more symptom days than did older MDQ-positive subjects. MDQ-positive women reported more disruption in social and family life, while MDQ-positive men reported being jailed, arrested, and convicted for crimes. Anxiety (30{\%} vs. 6{\%}), panic attacks (18{\%} vs. 4{\%}), migraine (24{\%} vs. 11{\%}), asthma (17{\%} vs. 10{\%}), and allergies (42{\%} vs. 29{\%}) were significantly (p < .05) more common in MDQ-positive versus MDQ-negative subjects. Conclusion: Bipolar disorder, as identified in a community sample using the Mood Disorder Questionnaire, was significantly associated with negative impact on the performance of workrelated, leisure, and interpersonal activities.",
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AU - Hirschfeld, Robert M A

AU - Reed, Michael

AU - Davies, Marilyn A.

AU - Frye, Mark A.

AU - Keck, Paul E.

AU - Lewis, Lydia

AU - McElroy, Susan L.

AU - McNulty, James P.

AU - Wagner, Karen

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N2 - Background: Bipolar disorder is a chronic psychiatric illness characterized by depression and at least 1 manic or hypomanic episode during the lifetime of the illness. Bipolar symptoms have been associated with significant functional impairment. We conducted a study to determine the psychosocial impact of bipolar disorder in a U.S. community sample. Method: 3059 subjects were selected from a large epidemiologic study of bipolar prevalence that used the Mood Disorder Questionnaire (MDQ) to screen for bipolar I and II disorder. Subjects were surveyed from April 24, 2001, to August 6, 2001, using the Sheehan Disability Scale and the Social Adjustment Scale-Self Report. Comorbid disease data were also collected. Results: Of the 3059 subjects surveyed, 2450 (80%) returned completed surveys: 1167 (48%) subjects screened positive for bipolar disorder based on MDQ scores; 1283 (52%) screened negative. MDQ-positive subjects reported significantly (p < .0001) more difficulties with workrelated performance, social/leisure activities, and social/family interactions compared with MDQ-negative subjects. Younger subjects, aged 18 to 34 years, reported significantly (p = .003) more symptom days than did older MDQ-positive subjects. MDQ-positive women reported more disruption in social and family life, while MDQ-positive men reported being jailed, arrested, and convicted for crimes. Anxiety (30% vs. 6%), panic attacks (18% vs. 4%), migraine (24% vs. 11%), asthma (17% vs. 10%), and allergies (42% vs. 29%) were significantly (p < .05) more common in MDQ-positive versus MDQ-negative subjects. Conclusion: Bipolar disorder, as identified in a community sample using the Mood Disorder Questionnaire, was significantly associated with negative impact on the performance of workrelated, leisure, and interpersonal activities.

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