Impact of bronchial circulation on bronchial exudates following combined burn and smoke inhalation injury in sheep

Naoki Morita, Perenlei Enkhbaatar, Dirk M. Maybauer, Marc O. Maybauer, Martin Westphal, Kazunori Murakami, Hal K. Hawkins, Robert A. Cox, Lillian D. Traber, Daniel L. Traber

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We previously reported bronchial circulation contributes to pulmonary edema and increases shunt fraction following smoke inhalation, and bronchial blood flow significantly increases in inhalation injury. We hypothesized reduction of bronchial blood flow reduces exudation to the airway and ameliorates lung injury from combined burn and smoke insults (B&S injury). Method: Merino ewes (n = 28) randomly divided into three groups: (1) bronchial artery ligated and injured (injury + ligation group); (2) bronchial artery left intact and injured (injury + no ligation group); (3) bronchial artery ligated but not injured (no injury + ligation group) were subjected to a flame burn and inhalation injury under halothane anesthesia. Parameters were analyzed using Scheffe's post hoc test (P < 0.05). All Groups were resuscitated with Ringer lactate solution and placed on a ventilator for 48 h. Results: Pulmonary gas exchange (PaO 2/FiO 2) improved in injury + ligation group. Further, obstruction score, an index of airway cast formation, significantly changed between injury + no ligation group compared to both ligation groups. Conclusion: Bronchial circulation plays a significant role in lung injury after B&S injury, and reduction of bronchial blood flow by bronchial artery ligation reduces bronchial exudates, resulting in improved gas exchange.

Original languageEnglish (US)
Pages (from-to)465-473
Number of pages9
JournalBurns
Volume37
Issue number3
DOIs
StatePublished - May 2011

Fingerprint

Smoke Inhalation Injury
Exudates and Transudates
Sheep
Ligation
Bronchial Arteries
Wounds and Injuries
Lung Injury
Smoke
Inhalation
Inhalation Burns
Pulmonary Gas Exchange
Halothane
Pulmonary Edema
Mechanical Ventilators
Anesthesia
Gases

Keywords

  • Acute lung injury
  • Airway cast formation
  • ARDS
  • Bronchial artery ligation
  • Bronchial circulation
  • Bronchial exudation
  • Inhalation injury

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine
  • Surgery

Cite this

Morita, N., Enkhbaatar, P., Maybauer, D. M., Maybauer, M. O., Westphal, M., Murakami, K., ... Traber, D. L. (2011). Impact of bronchial circulation on bronchial exudates following combined burn and smoke inhalation injury in sheep. Burns, 37(3), 465-473. https://doi.org/10.1016/j.burns.2010.11.005

Impact of bronchial circulation on bronchial exudates following combined burn and smoke inhalation injury in sheep. / Morita, Naoki; Enkhbaatar, Perenlei; Maybauer, Dirk M.; Maybauer, Marc O.; Westphal, Martin; Murakami, Kazunori; Hawkins, Hal K.; Cox, Robert A.; Traber, Lillian D.; Traber, Daniel L.

In: Burns, Vol. 37, No. 3, 05.2011, p. 465-473.

Research output: Contribution to journalArticle

Morita, N, Enkhbaatar, P, Maybauer, DM, Maybauer, MO, Westphal, M, Murakami, K, Hawkins, HK, Cox, RA, Traber, LD & Traber, DL 2011, 'Impact of bronchial circulation on bronchial exudates following combined burn and smoke inhalation injury in sheep', Burns, vol. 37, no. 3, pp. 465-473. https://doi.org/10.1016/j.burns.2010.11.005
Morita, Naoki ; Enkhbaatar, Perenlei ; Maybauer, Dirk M. ; Maybauer, Marc O. ; Westphal, Martin ; Murakami, Kazunori ; Hawkins, Hal K. ; Cox, Robert A. ; Traber, Lillian D. ; Traber, Daniel L. / Impact of bronchial circulation on bronchial exudates following combined burn and smoke inhalation injury in sheep. In: Burns. 2011 ; Vol. 37, No. 3. pp. 465-473.
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